Description

Pal-D-Glu-Otbu is a protected amino acid derivative, specifically a tert-butyl ester of D-glutamic acid. This compound is a crucial chiral building block in the synthesis of complex peptides and pharmaceutical intermediates, offering high stereochemical purity and stability. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for advanced drug discovery and development projects.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of peptide-based active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to introduce the D-glutamic acid residue with a protected side chain.
• Protease Inhibitor Research: Serves as a precursor in the development of enzyme inhibitors targeting glutamic acid-specific proteases.
• Bioconjugation: Employed in the preparation of labeled peptides or peptide-drug conjugates for diagnostic and therapeutic applications.
• Chemical Biology Probes: Utilized to create modified peptides for studying protein-protein interactions and cellular signaling pathways.
• Fine Chemical Synthesis: Acts as a building block for non-peptidic molecules requiring a chiral, protected glutamic acid moiety.

Basic Information

Product Name	Pal-D-Glu-Otbu
CAS No.	1855872-05-7
Molecular Formula	C19H37NO5
Molecular Weight	359.51 g/mol
Synonyms	N-Palmitoyl-D-glutamic acid 1-tert-butyl ester; D-Glutamic acid, N-hexadecanoyl-, 1-(1,1-dimethylethyl) ester; Pal-D-Glu(OtBu)-OH; N-Hexadecanoyl-D-glutamic acid tert-butyl ester; tert-Butyl N-palmitoyl-D-glutamate; Palmitoyl-D-glutamic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our Pal-D-Glu-Otbu is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the high standards required for research and cGMP manufacturing. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically ≥98% by HPLC), and specific tests is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. The product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when possible.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% D-isomer
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.