Description

2-Bromo-3-Fluorophenylacetylene is a high-purity, halogenated aromatic alkyne building block of significant importance in advanced organic synthesis. Its unique structure, featuring both bromine and fluorine substituents on a phenylacetylene core, makes it a versatile intermediate for constructing complex molecular architectures. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for applications such as cross-coupling reactions and the synthesis of novel functional materials.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for creating novel compounds via Sonogashira, Suzuki, and other palladium-catalyzed cross-coupling reactions.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, where the introduction of fluorine and bromine atoms can modulate biological activity and environmental stability.
• Material Science: Serves as a monomer or precursor for constructing conjugated polymers, organic semiconductors, and liquid crystals, where the acetylene group enables linear chain extension.
• Chemical Synthesis: Acts as a versatile synthon in organic chemistry for the preparation of more complex heterocyclic and polycyclic compounds through cycloaddition and annulation reactions.
• Ligand & Catalyst Development: Employed in the synthesis of specialized phosphine or N-heterocyclic carbene (NHC) ligands that incorporate halogenated aryl groups for tuning catalytic properties.
• Fluorine Chemistry Studies: A valuable substrate for investigating the electronic and steric effects of ortho-fluorine substitution in aromatic systems on reaction pathways.

Basic Information

Item	Detail
Product Name	2-Bromo-3-Fluorophenylacetylene
CAS No.	1855543-30-4
Molecular Formula	C8H4BrF
Molecular Weight	199.02 g/mol
Synonyms	1-Bromo-2-fluoro-3-ethynylbenzene; 3-Ethynyl-2-fluorobromobenzene; 2-Fluoro-3-bromophenylacetylene; (2-Bromo-3-fluorophenyl)ethyne; 3-Bromo-2-fluorophenylacetylene
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-3-Fluorophenylacetylene is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the compound meets the high-purity standards required for research and development. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment, confirming compliance with customer specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to the light-sensitive nature of the compound, the container should be amber glass or opaque.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.