Description

(S)-1-[(R)-2-[Bis[4-(Trifluoromethyl)Phenyl]Phosphino]Ferrocenyl]Ethylbis[4-(Trifluoromethyl)Phenyl]Phosphine is a highly specialized, chiral ferrocenyl phosphine ligand, prized for its exceptional ability to induce stereoselectivity in transition metal-catalyzed reactions. Its value lies in enabling the synthesis of enantiomerically pure compounds, which are critical for developing advanced pharmaceuticals and fine chemicals. This ligand is essential for R&D chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries who require high-performance catalysts for asymmetric synthesis.

Application

• Asymmetric Hydrogenation: A key ligand for the enantioselective reduction of prochiral olefins, ketones, and imines to produce chiral intermediates for active pharmaceutical ingredients (APIs).
• Asymmetric C-C Bond Formation: Catalyzes critical reactions like cross-coupling, allylic substitution, and hydroformylation with high enantiomeric excess (ee).
• Pharmaceutical Intermediate Synthesis: Used in the production of enantiopure building blocks for drugs targeting central nervous system disorders, cardiovascular diseases, and infectious diseases.
• Agrochemical Manufacturing: Enables the creation of chiral pesticides and herbicides with improved efficacy and environmental profiles.
• Fine Chemical and Fragrance Production: Applied in the synthesis of complex, high-value chiral molecules for flavors, fragrances, and advanced materials.
• Catalyst Screening and Development: Serves as a benchmark or component in catalyst libraries for discovering new asymmetric transformations in academic and industrial research.

Basic Information

Product Name	(S)-1-[(R)-2-[Bis[4-(Trifluoromethyl)Phenyl]Phosphino]Ferrocenyl]Ethylbis[4-(Trifluoromethyl)Phenyl]Phosphine
CAS No.	1854066-56-0
Molecular Formula	C45H30F12FeP2
Molecular Weight	892.50 g/mol
Synonyms	(S,R)-JOSIPHOS SL-J009-1; (S)-1-[(R)-2-(Bis[4-(trifluoromethyl)phenyl]phosphino)ferrocenyl]ethyldi(4-(trifluoromethyl)phenyl)phosphine; Josiphos SL-J009-1 Ligand; (S)-1-((R)-2-(Bis(4-(trifluoromethyl)phenyl)phosphino)ferrocenyl)ethyldi(4-(trifluoromethyl)phenyl)phosphine; J009-1; SL-J009-1; Chiral Ferrocenyl Diphosphine Ligand
EINECS	Contact for details

Quality Control

Every batch of our chiral phosphine ligands is produced and tested under strict quality management to ensure consistency and performance. Standard quality parameters include purity assessment by HPLC/NMR and confirmation of chiral integrity. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and specific tests is provided with each shipment. We support compliance with cGMP and ISO 9001 standards for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry place. This compound is easily oxidized and light-sensitive; prolonged exposure to air or light should be avoided to maintain ligand efficacy.

Specification

Item	Specification
Appearance	Orange to red powder or crystals
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.