Description

n-[(1S)-2-(Diphenylphosphino)-1-Phenylethyl]-3,5-Bis(Trifluoromethyl)-Benzamide is a sophisticated chiral phosphine ligand, a critical component in asymmetric catalysis. Its value lies in enabling highly enantioselective transformations, crucial for producing single-isomer pharmaceuticals and fine chemicals. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors seeking to optimize stereoselective synthesis.

Application

• Asymmetric Hydrogenation Catalysis: A key ligand for the enantioselective reduction of prochiral olefins, ketones, and imines in pharmaceutical intermediate synthesis.
• Cross-Coupling Reactions: Facilitates palladium-catalyzed C-C and C-X bond-forming reactions with high stereocontrol.
• Pharmaceutical Intermediate Manufacturing: Used in the production of active pharmaceutical ingredients (APIs) requiring specific chiral centers.
• Agrochemical Synthesis: Enables the creation of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Academic & Industrial R&D: A valuable tool for developing new catalytic methodologies and exploring novel reaction pathways.
• Fine Chemical Production: Applied in the synthesis of complex, high-value flavor, fragrance, and specialty chemical compounds.

Basic Information

Product Name	n-[(1S)-2-(Diphenylphosphino)-1-Phenylethyl]-3,5-Bis(Trifluoromethyl)-Benzamide
CAS No.	1853342-57-0
Molecular Formula	C29H22F6NOP
Molecular Weight	545.46 g/mol
Synonyms	(S)-N-(2-(Diphenylphosphino)-1-phenylethyl)-3,5-bis(trifluoromethyl)benzamide; (S)-3,5-Bis(trifluoromethyl)-N-[2-(diphenylphosphino)-1-phenylethyl]benzamide; (S)-XYL-P-Phos Benzamide Derivative; Chiral Phosphine-Benzamide Ligand; Josiphos-type Ligand Analog; Asymmetric Hydrogenation Ligand CAS 1853342-57-0
EINECS	Contact for details

Quality Control

Every batch of our chiral ligands is produced under strict quality-controlled conditions to ensure exceptional purity and performance consistency for catalytic applications. We provide comprehensive Certificates of Analysis (COA) detailing chiral purity (enantiomeric excess), chemical purity, and identity confirmation. Our quality systems support development under cGMP and ISO guidelines for traceability and reliability.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, well-ventilated area. Keep away from strong bases and fluorides. Due to its sensitivity, allow the container to reach ambient temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.