Description

[S(R)]-n-[(1S)-1-[(Diphenylphosphino)Methyl]-2,2-Dimethylpropyl]-2-Methyl-2-Propanesulfinamide is a sophisticated chiral sulfinamide-phosphine hybrid ligand, a key building block in asymmetric synthesis. Its value lies in its ability to induce high enantioselectivity in transition metal-catalyzed reactions, enabling the production of single-enantiomer intermediates critical for advanced pharmaceuticals. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries who require precise stereochemical control.

Application

• As a chiral ligand in asymmetric hydrogenation, hydroformylation, and cross-coupling reactions.
• For the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs) and key chiral intermediates.
• In catalyst development and screening for novel asymmetric transformations in academic and industrial research.
• For the preparation of high-value agrochemicals and flavor & fragrance compounds requiring specific stereochemistry.
• As a critical reagent in process chemistry to optimize yield and enantiomeric excess (ee) in scale-up.

Basic Information

Product Name	[S(R)]-n-[(1S)-1-[(Diphenylphosphino)Methyl]-2,2-Dimethylpropyl]-2-Methyl-2-Propanesulfinamide
CAS No.	1853342-54-7
Molecular Formula	C22H32NOPS
Molecular Weight	389.53 g/mol
Synonyms	(S)-tert-Butanesulfinamide, (R)-DTBM-SEGPHOS derivative; (S)-N-[(1R)-1-[(Diphenylphosphino)methyl]-2,2-dimethylpropyl]-2-methyl-2-propanesulfinamide; Chiral Sulfinyl Phosphine Ligand; tert-Butylsulfinamide-DTBM hybrid ligand; (S)-t-BuSO-(R)-DTBM-SEGPHOS precursor; Asymmetric synthesis ligand CAS 1853342-54-7; P,S-Bidentate ligand
EINECS	Contact for details

Quality Control

Every batch of our chiral ligands undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure exceptional chemical and enantiomeric purity. We provide comprehensive Certificates of Analysis (COA) detailing all specifications, supporting cGMP and ISO 9001 compliant workflows for critical pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to prevent oxidation and ensure long-term stability. The container should be kept in a cool, dry, and well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.