Description

[2',4'-Bis(1,1-Dimethylethyl)-6'-Methoxy[1,1'-Biphenyl]-2-Yl]Dicyclohexylphosphine CAS NO 1848244-75-6 is a specialized, sterically hindered phosphine ligand designed for advanced catalytic applications. Its value lies in enabling highly efficient and selective cross-coupling reactions, which are fundamental to modern pharmaceutical and fine chemical synthesis. This compound is essential for R&D chemists and process engineers in the pharmaceutical, agrochemical, and advanced materials sectors who require robust and tunable catalysts for complex molecular construction.

Application

• Catalyst Ligand for Cross-Coupling Reactions: A key component in palladium-catalyzed Suzuki-Miyaura, Buchwald-Hartwig, and Negishi couplings for C-C and C-N bond formation.
• Pharmaceutical Intermediate Synthesis: Enables the efficient and selective synthesis of complex, high-value active pharmaceutical ingredients (APIs) and drug candidates.
• Agrochemical Manufacturing: Used in the catalytic synthesis of novel herbicides, fungicides, and insecticides requiring specific stereochemistry.
• Materials Science Research: Facilitates the development of organic electronic materials, polymers, and liquid crystals through controlled polymerization and functionalization.
• Process Chemistry & Scale-Up: Provides improved catalyst stability and turnover numbers (TON) for more economical and reliable industrial-scale chemical production.
• Academic & Industrial R&D: A valuable tool for methodological development in synthetic organic chemistry laboratories.

Basic Information

Product Name	[2',4'-Bis(1,1-Dimethylethyl)-6'-Methoxy[1,1'-Biphenyl]-2-Yl]Dicyclohexylphosphine
CAS No.	1848244-75-6
Molecular Formula	C35H53OP
Molecular Weight	520.77 g/mol
Synonyms	Biphenylphosphine Ligand; Dicyclohexyl(2',4'-di-tert-butyl-6'-methoxy-[1,1'-biphenyl]-2-yl)phosphine; tBuBrettPhos; BrettPhos-type ligand; 2-(Dicyclohexylphosphino)-2',4',6'-triisopropylbiphenyl analog; Sterically hindered biarylphosphine; Buchwald ligand derivative; Contact for additional trade names.
EINECS	Contact for details

Quality Control

Every batch of our phosphine ligands is produced and tested under strict quality management protocols to ensure consistency and performance. Standard quality parameters include purity assessment via NMR and HPLC, with residual solvent analysis. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with each shipment. We support development and regulatory needs with documentation suitable for cGMP and ISO 9001 compliant environments.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. Due to its sensitivity to oxidation, the container should be purged with inert gas after each opening to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Purity (NMR)	≥ 97.0%
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.