Description

(S)-3,3'-Bis[3,5-Bis(Trifluoromethyl)Phenyl]-1,1'-Binaphthyl-2,2'-Diyl-n-Triflyl Phosphoramide is a sophisticated chiral phosphoramide ligand, a key building block in asymmetric synthesis. Its value lies in its ability to act as a highly selective catalyst or ligand for enantioselective transformations, crucial for producing single-isomer pharmaceuticals and fine chemicals. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity, specialized chiral auxiliaries.

Application

• Asymmetric Catalysis: As a privileged chiral ligand for transition metal-catalyzed reactions such as hydrogenation, cross-coupling, and C-H activation.
• Pharmaceutical Intermediate Synthesis: Enabling the enantioselective construction of complex drug molecules, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Development: Used in the synthesis of chiral active ingredients for herbicides, fungicides, and insecticides where specific stereochemistry impacts biological activity.
• Methodology Research: A valuable tool for academic and industrial researchers developing new catalytic asymmetric methodologies.
• Fine Chemical Production: Facilitating the manufacture of enantiomerically pure flavors, fragrances, and electronic chemicals.
• Chiral Resolution: Potential use in the separation of racemic mixtures via diastereomeric complex formation.

Basic Information

Product Name	(S)-3,3'-Bis[3,5-Bis(Trifluoromethyl)Phenyl]-1,1'-Binaphthyl-2,2'-Diyl-n-Triflyl Phosphoramide
CAS No.	1836233-61-4
Molecular Formula	C48H24F18NO5PS2
Molecular Weight	1123.79 g/mol
Synonyms	(S)-BINOL-Derived Triflyl Phosphoramide Ligand; (S)-3,3'-Bis(3,5-bis(trifluoromethyl)phenyl)-1,1'-binaphthyl-2,2'-diyl Phosphorotrifluoridate; (S)-BINAP-TFPA; (S)-DTB-BINOL Triflyl Phosphoramide; Chiral Phosphoric Acid Triflimide Derivative; (S)-H8-BINOL-Based Triflamide; Asymmetric Organocatalyst Ligand; CAS 1836233-61-4
EINECS	Contact for details

Quality Control

Our production of this high-value chiral chemical adheres to stringent quality control protocols to ensure batch-to-batch consistency and optimal catalytic performance. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and chiral analysis to confirm identity, purity, and enantiomeric excess (ee). A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support development under cGMP guidelines where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) when opening the container for use to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.