Description

1-Bromo-4-Ethoxy-2,5-Difluorobenzene is a high-purity fluorinated and brominated aromatic building block of significant importance in advanced organic synthesis. Its unique structure, featuring both halogen and alkoxy substituents, makes it a versatile and valuable intermediate for constructing complex molecules. This compound is primarily sought after by research and development chemists and process engineers in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring difluorobenzene and bromoarene motifs for bioactivity or metabolic stability.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides where the fluorine and bromine atoms contribute to product efficacy and environmental persistence profiles.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated aromatic cores in electronic chemicals, contributing to the dielectric and optoelectronic properties of advanced display materials.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, and Buchwald-Hartwig aminations, enabling the formation of new carbon-carbon and carbon-heteroatom bonds.
• Functional Material Research: Employed in academic and industrial R&D for creating novel polymers, ligands for catalysis, and specialty fine chemicals with tailored properties.

Basic Information

Product Name	1-Bromo-4-Ethoxy-2,5-Difluorobenzene
CAS No.	1826110-08-0
Molecular Formula	C8H7BrF2O
Molecular Weight	237.04 g/mol
Synonyms	4-Bromo-1-ethoxy-2,5-difluorobenzene; 2,5-Difluoro-4-bromophenetole; 1-Ethoxy-4-bromo-2,5-difluorobenzene; Benzene, 1-bromo-4-ethoxy-2,5-difluoro-; 4-Bromo-2,5-difluorophenetole; 2,5-Difluoro-1-ethoxy-4-bromobenzene
EINECS	Contact for details

Quality Control

Our 1-Bromo-4-Ethoxy-2,5-Difluorobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC/HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥97.0% (Standard Grade)
Assay	≥98.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.