Description

S(R)]-n-[(1S)-2-(Diphenylphosphino)-1-Phenylethyl]-N,2-Dimethyl-2-Propanesulfinamide CAS NO 1824731-37-4 is a high-purity, chiral sulfinamide-phosphine hybrid ligand. This compound is a critical building block in asymmetric synthesis, valued for its ability to induce high enantioselectivity in transition metal-catalyzed reactions. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Asymmetric Hydrogenation: A key chiral ligand for the enantioselective reduction of prochiral olefins, ketones, and imines.
• Pharmaceutical Intermediate Synthesis: Used in the catalytic preparation of chiral amines and alcohols, which are core structures in many drug molecules.
• Cross-Coupling Reactions: Employed as a ligand in palladium-catalyzed Suzuki, Heck, and Buchwald-Hartwig amination reactions to control stereochemistry.
• Academic & Industrial R&D: A valuable tool for chemists exploring new catalytic methodologies and reaction pathways in organic synthesis.
• Fine Chemical Production: Facilitates the manufacture of enantiomerically pure agrochemicals, flavors, and fragrances.
• Catalyst Library Development: Used to create proprietary catalyst systems for contract research and manufacturing organizations (CROs/CMOs).

Basic Information

Product Name	S(R)]-n-[(1S)-2-(Diphenylphosphino)-1-Phenylethyl]-N,2-Dimethyl-2-Propanesulfinamide
CAS No.	1824731-37-4
Molecular Formula	C25H30NOPS
Molecular Weight	423.55 g/mol
Synonyms	(S)-N-[(1S)-2-(Diphenylphosphino)-1-phenylethyl]-2-methylpropane-2-sulfinamide; (S)-tert-Butanesulfinamide, N-[(1S)-2-(diphenylphosphino)-1-phenylethyl]-; Chiral Sulfinamide-Phosphine Ligand; Josiphos-type Sulfinamide Ligand; (S,S)-Sulfinamidophosphine; Asymmetric Synthesis Ligand; P,S-Bidentate Ligand; (S)-N-((S)-1-(Diphenylphosphino)-2-phenylethyl)-2-methylpropane-2-sulfinamide
EINECS	Contact for details

Quality Control

Our S(R)]-n-[(1S)-2-(Diphenylphosphino)-1-Phenylethyl]-N,2-Dimethyl-2-Propanesulfinamide is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chiral purity. Each lot is characterized by advanced analytical techniques, including chiral HPLC and NMR spectroscopy. Certificates of Analysis (COA) detailing purity, enantiomeric excess (ee), and full spectroscopic data are provided with every shipment to support your regulatory and research needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to maintain stability and prevent oxidation. The container should be kept in a cool, dry, and well-ventilated area, separate from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.