Description

3,4-Dichloro-5-(Trifluoromethyl)Phenylacetonitrile is a high-value, multi-functional aromatic nitrile building block. This compound matters for its unique molecular architecture, combining a phenylacetonitrile core with strategically positioned chlorine and trifluoromethyl substituents, which are critical for modulating the electronic and steric properties of advanced molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel small molecule drugs, particularly in kinase inhibitor and antiviral research.
• Agrochemical Active Ingredient Synthesis: Used in constructing advanced herbicides, fungicides, and insecticides where the CF3 and Cl groups enhance bioactivity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of functionalized polymers, liquid crystals, and organic electronic materials.
• Custom Synthesis and Contract Manufacturing: A critical building block for fine chemical and CDMO (Contract Development and Manufacturing Organization) projects requiring bespoke fluorinated intermediates.

Basic Information

Product Name	3,4-Dichloro-5-(Trifluoromethyl)Phenylacetonitrile
CAS No.	1824274-76-1
Molecular Formula	C9H4Cl2F3N
Molecular Weight	254.04 g/mol
Synonyms	2-(3,4-Dichloro-5-(trifluoromethyl)phenyl)acetonitrile; (3,4-Dichloro-5-(trifluoromethyl)phenyl)acetonitrile; 3,4-Dichloro-α-(trifluoromethyl)benzeneacetonitrile; 2-(3,4-Dichloro-5-(trifluoromethyl)phenyl)ethanenitrile; Benzeneacetonitrile, 3,4-dichloro-α-(trifluoromethyl)-; 1824274-76-1; 3,4-Dichloro-5-trifluoromethylphenylacetonitrile
EINECS	Contact for details

Quality Control

Our 3,4-Dichloro-5-(Trifluoromethyl)Phenylacetonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports compliance with cGMP and ICH guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.