Description

2-(2-Bromo-5-Fluorophenyl)-2,2-Difluoroacetic Acid is a high-value, multi-fluorinated aromatic building block essential for advanced organic synthesis. This compound matters for its role as a critical precursor in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where its unique halogen and fluorine substitution pattern enables precise molecular modifications. It is primarily needed by research chemists and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecules with targeted biological activity.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Research: Used in the development of next-generation herbicides, fungicides, and insecticides, where the difluoroacetic acid moiety can enhance metabolic stability and bioavailability.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science: Employed in the synthesis of fluorinated polymers and liquid crystals, contributing to unique material properties like chemical resistance and thermal stability.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	2-(2-Bromo-5-Fluorophenyl)-2,2-Difluoroacetic Acid
CAS No.	1824005-97-1
Molecular Formula	C8H4BrF3O2
Molecular Weight	269.02 g/mol
Synonyms	2-(2-Bromo-5-fluorophenyl)-2,2-difluoroacetic acid; α,α-Difluoro-2-bromo-5-fluorophenylacetic Acid; 2-Bromo-5-fluorophenyl(difluoro)acetic Acid; (2-Bromo-5-fluorophenyl)difluoroacetic Acid; 2,2-Difluoro-2-(2-bromo-5-fluorophenyl)acetic Acid; Difluoro(2-bromo-5-fluorophenyl)acetic Acid; 1824005-97-1
EINECS	Contact for details

Quality Control

Our 2-(2-Bromo-5-Fluorophenyl)-2,2-Difluoroacetic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and scale-up. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with cGMP and ISO 9001 standards for pharmaceutical intermediates, and specifications can be aligned with client-specific requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.