Description

2-(4-(((9H-Fluoren-9-Yl)Methoxy)Carbonyl)Piperazin-2-Yl)Acetic Acid Hydrochloride is a high-purity, protected amino acid derivative essential for advanced peptide synthesis. This compound serves as a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled assembly of complex peptides and proteins. It is primarily utilized by pharmaceutical R&D teams, biotechnology firms, and fine chemical manufacturers developing therapeutic peptides, diagnostic agents, and novel bioactive molecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key Fmoc-protected intermediate for the sequential coupling of piperazine-containing amino acid residues.
• Pharmaceutical Research: Building block for the development of novel peptide-based drug candidates targeting GPCRs, enzymes, and other biological pathways.
• Bioconjugation: Used to introduce functionalized piperazine linkers into peptides for subsequent labeling or attachment to other molecules (e.g., antibodies, polymers).
• Combinatorial Chemistry: A valuable reagent in libraries for high-throughput screening to discover new bioactive compounds.
• Chemical Biology Probes: Synthesis of tool compounds and probes for studying protein-protein interactions and cellular processes.
• Custom Peptide Services: A critical raw material for CROs and CDMOs offering bespoke peptide manufacturing.

Basic Information

Product Name	2-(4-(((9H-Fluoren-9-Yl)Methoxy)Carbonyl)Piperazin-2-Yl)Acetic Acid Hydrochloride
CAS No.	1823497-18-2
Molecular Formula	C23H25N3O5 • HCl
Molecular Weight	483.93 g/mol (Free base: 447.46 g/mol)
Synonyms	Fmoc-Pip(2-Ac)-OH • HCl; Fmoc-2-(Piperazin-2-yl)acetic acid hydrochloride; N-α-Fmoc-N'-δ-(2-carboxyethyl)-L-2,4-diaminobutanoic acid (piperazine analog) hydrochloride; 2-[4-[(9H-Fluoren-9-ylmethoxy)carbonyl]piperazin-2-yl]acetic acid hydrochloride; Fmoc-Pip(Ac)-OH • HCl; Fmoc-protected Piperazine-2-acetic Acid Hydrochloride
EINECS	Contact for details

Quality Control

Our 2-(4-(((9H-Fluoren-9-Yl)Methoxy)Carbonyl)Piperazin-2-Yl)Acetic Acid Hydrochloride is manufactured under strict quality systems to ensure batch-to-batch consistency for sensitive synthetic applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality protocols are designed to meet the stringent requirements of pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This material is hygroscopic (moisture-sensitive); ensure containers are sealed under inert atmosphere after each use to maintain stability and purity. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH Q3C guidelines
Assay (Titration)	97.0% - 102.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.