Description

Ethyl 3,3-Difluorobicyclo[3.1.0]Hexane-6-Carboxylate is a high-value fluorinated bicyclic building block used in advanced organic synthesis. This compound is critical for medicinal chemistry research, enabling the introduction of unique three-dimensional, fluorine-containing scaffolds into target molecules. It is primarily sought by pharmaceutical R&D teams and fine chemical manufacturers for developing novel active pharmaceutical ingredients (APIs) and agrochemicals. The CAS number for this product is 1823348-86-2.

Application

This versatile fluorinated intermediate is designed for sophisticated synthetic applications across several high-tech industries.

• Pharmaceutical Intermediate: A key building block for synthesizing novel drug candidates, particularly in central nervous system (CNS) and metabolic disease research.
• Agrochemical Synthesis: Used in the development of new-generation herbicides and pesticides with enhanced activity and environmental profiles.
• Material Science: Serves as a precursor for specialty polymers and advanced materials requiring fluorinated motifs for specific properties like chemical resistance.
• Ligand & Catalyst Development: Employed in the creation of novel chiral ligands and organocatalysts for asymmetric synthesis.
• Fluorine Chemistry Research: An essential reagent for academic and industrial research exploring new fluorination methodologies and the effects of the difluorocyclopropane motif.

Basic Information

Product Name	Ethyl 3,3-Difluorobicyclo[3.1.0]Hexane-6-Carboxylate
CAS No.	1823348-86-2
Molecular Formula	C10H14F2O2
Molecular Weight	204.22 g/mol
Synonyms	6-(Ethoxycarbonyl)-3,3-difluorobicyclo[3.1.0]hexane; Ethyl 3,3-Difluoro-6-bicyclo[3.1.0]hexanecarboxylate; 3,3-Difluorobicyclo[3.1.0]hexane-6-carboxylic Acid Ethyl Ester; Bicyclo[3.1.0]hexane-6-carboxylic acid, 3,3-difluoro-, ethyl ester; 1823348-86-2; Ethyl 3,3-difluorobicyclo[3.1.0]hexane-6-carboxylate
EINECS	Contact for details

Quality Control

Our Ethyl 3,3-Difluorobicyclo[3.1.0]Hexane-6-Carboxylate is produced under strict quality management systems. Every batch undergoes rigorous analytical testing, including NMR, HPLC, and GC-MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. We support cGMP compliance for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its properties as a fluoride/strong alkali and highly volatile compound, ensure containers are kept tightly sealed and away from incompatible materials. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.