Description

tert-Butyl n-{7-Azabicyclo[2.2.1]Heptan-2-Yl}Carbamate is a high-purity, advanced pharmaceutical intermediate featuring a unique bridged bicyclic amine structure. This compound is critical for medicinal chemistry research and development, serving as a key building block for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in developing new therapeutic agents, particularly in areas requiring complex molecular scaffolds.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of complex drug candidates, particularly in central nervous system (CNS) and antiviral research.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies due to its rigid, three-dimensional azabicyclic core.
• Peptidomimetic Synthesis: Serves as a constrained amino acid analog for creating novel peptide-like molecules with enhanced metabolic stability.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands and organocatalysts for asymmetric synthesis.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds under cGMP conditions.

Basic Information

Product Name	tert-Butyl n-{7-Azabicyclo[2.2.1]Heptan-2-Yl}Carbamate
CAS No.	1823327-72-5
Molecular Formula	C11H20N2O2
Molecular Weight	212.29 g/mol
Synonyms	2-[(tert-Butoxycarbonyl)amino]-7-azabicyclo[2.2.1]heptane; tert-Butyl (7-azabicyclo[2.2.1]heptan-2-yl)carbamate; 7-Azabicyclo[2.2.1]heptane-2-carboxamide, N-(1,1-dimethylethoxy)-; N-Boc-2-amino-7-azabicyclo[2.2.1]heptane; Boc-7-Azanorbornane-2-amine; 1823327-72-5; (1R,2S,4S)-2-[(tert-Butoxycarbonyl)amino]-7-azabicyclo[2.2.1]heptane (for specific stereoisomer)
EINECS	Contact for details

Quality Control

Our tert-Butyl n-{7-Azabicyclo[2.2.1]Heptan-2-Yl}Carbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity, to ensure compliance with stringent pharmaceutical-grade specifications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We support development and commercial projects with material suitable for research use, pre-clinical, and cGMP applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e. (for specified isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.