Description

Fmoc-n-Methyl-L-Alloisoleucine CAS NO 1821797-58-3 is a high-purity, non-proteinogenic amino acid derivative specifically engineered for advanced peptide synthesis. This compound is critical for introducing the sterically hindered, N-methylated alloisoleucine residue into peptide chains, a modification known to enhance metabolic stability and modulate biological activity. It is an essential building block for research and development teams in pharmaceutical discovery, particularly those focused on novel therapeutics, peptide-based diagnostics, and bioactive compound libraries.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc/t-Bu strategy, enabling the controlled incorporation of N-methyl-alloisoleucine.
• Pharmaceutical R&D: Used in the synthesis of peptide drug candidates where improved protease resistance and conformational control are required.
• Peptidomimetics Development: Essential for creating constrained peptide analogs and mimetics in medicinal chemistry programs.
• Combinatorial Chemistry: Serves as a valuable building block for generating diverse peptide libraries for high-throughput screening.
• Bioconjugation & Probe Synthesis: Utilized in the preparation of labeled peptides for biochemical assays and imaging studies.
• Academic Research: Fundamental tool for studying structure-activity relationships (SAR) and peptide folding in academic laboratories.

Basic Information

Product Name	Fmoc-n-Methyl-L-Alloisoleucine
CAS No.	1821797-58-3
Molecular Formula	C22H25NO5
Molecular Weight	383.44 g/mol
Synonyms	Fmoc-N-Me-L-allo-Ile-OH; (2S,3S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-methylpentanoic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-L-alloisoleucine; Fmoc-N-methyl-L-allo-isoleucine; Fmoc-N-Me-allo-Ile; N-Fmoc-N-methyl-L-alloisoleucine; Nα-Fmoc-Nα-methyl-L-alloisoleucine
EINECS	Contact for details

Quality Control

Every batch of Fmoc-n-Methyl-L-Alloisoleucine is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Our products are suitable for demanding research and development applications. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with in-house specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.