Description

(2S)-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)-3-(6-Methoxypyridin-3-Yl)Propanoic Acid is a high-purity, non-natural amino acid derivative featuring a 6-methoxypyridin-3-yl side chain and an Fmoc-protected α-amino group. This compound is a critical building block for the solid-phase peptide synthesis (SPPS) of peptides containing methoxypyridine-modified residues, enabling advanced research in medicinal chemistry and biochemistry. It is primarily utilized by pharmaceutical R&D teams, CROs, and academic laboratories focused on developing novel peptide-based therapeutics, diagnostics, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid, it is a fundamental reagent for the automated synthesis of custom peptides.
• Medicinal Chemistry & Drug Discovery: Used to incorporate the 6-methoxypyridin-3-yl moiety into peptide sequences to modulate bioactivity, solubility, and receptor binding affinity for novel drug candidates.
• Bioconjugation & Probe Development: Serves as a precursor for creating labeled peptides or peptide-drug conjugates used in imaging, targeting, and diagnostic applications.
• Chemical Biology Research: Enables the study of protein-protein interactions and enzyme mechanisms by introducing specific, non-canonical amino acids into synthetic peptides.
• Process Development & Scale-Up: Supports the development and optimization of manufacturing processes for peptide APIs under GMP conditions.

Basic Information

Product Name	(2S)-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)-3-(6-Methoxypyridin-3-Yl)Propanoic Acid
CAS No.	1821775-88-5
Molecular Formula	C24H22N2O5
Molecular Weight	418.44 g/mol
Synonyms	Fmoc-3-(6-Methoxypyridin-3-yl)-L-alanine; Fmoc-3-(6-Methoxy-3-pyridyl)-L-alanine; Fmoc-(6-MeO-3-Pyridyl)-Ala-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-(6-methoxypyridin-3-yl)-L-alanine; (2S)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-3-(6-methoxypyridin-3-yl)propanoic acid; Fmoc-L-3-(6-Methoxypyridyl)alanine; Nα-Fmoc-3-(6-methoxy-3-pyridinyl)-L-alanine
EINECS	Contact for details

Quality Control

Every batch of our (2S)-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)-3-(6-Methoxypyridin-3-Yl)Propanoic Acid is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We provide Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles to ensure compliance with your research and development specifications. Our quality commitment supports applications requiring high-grade intermediates for pharmaceutical and biotech innovation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.