Description

(1S,3R)-3-Trifluoromethyl-Cyclohexanecarboxylic Acid CAS NO 1821707-08-7 is a high-purity, chiral fluorinated building block of significant interest in advanced organic synthesis. Its value lies in the unique combination of a rigid cyclohexane scaffold with a strategically positioned trifluoromethyl group, which is critical for modulating the physicochemical properties of target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating novel active ingredients with enhanced metabolic stability, bioavailability, and binding selectivity.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of new active pharmaceutical ingredients (APIs), especially in CNS, oncology, and metabolic disease research.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the CF₃ group improves lipophilicity and biological activity.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of specialty polymers and liquid crystals where fluorination alters material properties.
• Chemical Biology Probes: Utilized as a building block for creating fluorinated analogs of natural products or biomarkers for metabolic studies.

Basic Information

Product Name	(1S,3R)-3-Trifluoromethyl-Cyclohexanecarboxylic Acid
CAS No.	1821707-08-7
Molecular Formula	C₈H₁₁F₃O₂
Molecular Weight	196.17 g/mol
Synonyms	(1S,3R)-3-(Trifluoromethyl)cyclohexane-1-carboxylic acid; rel-(1S,3R)-3-(Trifluoromethyl)cyclohexanecarboxylic acid; 3-(Trifluoromethyl)cyclohexanecarboxylic Acid (enantiomer); trans-3-Trifluoromethylcyclohexanecarboxylic Acid; (1S,3R)-3-Trifluoromethyl-1-cyclohexanecarboxylic Acid; Bicyclo[4.2.0]octane-7-carboxylic acid, 1-(trifluoromethyl)-, (1S,7R)-rel-; (1S,3R)-3-Trifluoromethylcyclohexanecarboxylic Acid
EINECS	Contact for details

Quality Control

We maintain stringent quality control protocols for our chiral intermediates. Production is conducted under controlled conditions, and every batch is analyzed to ensure high chiral purity and chemical identity. Standard specifications include Chiral HPLC purity (typically >98.5%) and enantiomeric excess (e.e. >99%). Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and organic solvents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.5%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.