Description

5-Bromo-1-Chloro-3-Fluoro-2-Propoxybenzene is a high-purity halogenated aromatic ether building block of significant interest in advanced organic synthesis. Its value lies in its multifunctional structure, which provides multiple reactive sites for constructing complex molecules. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting CNS disorders and infectious diseases.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, leveraging its halogen-substituted aromatic core.
• Material Science Research: Serves as a precursor for synthesizing specialty monomers and ligands used in advanced polymers and metal-organic frameworks (MOFs).
• Liquid Crystal & OLED Materials: A potential intermediate in the development of fluorinated components for electronic display and lighting technologies.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Negishi, and Buchwald-Hartwig amination due to the bromo and chloro substituents.
• Custom Synthesis & Contract Manufacturing: Supplied to CROs and CDMOs for use in custom synthesis projects and scale-up processes.

Basic Information

Product Name	5-Bromo-1-Chloro-3-Fluoro-2-Propoxybenzene
CAS No.	1820712-69-3
Molecular Formula	C9H9BrClFO
Molecular Weight	267.52 g/mol
Synonyms	1-Bromo-3-chloro-5-fluoro-2-propoxybenzene; 2-Propoxy-5-bromo-1-chloro-3-fluorobenzene; Benzene, 5-bromo-1-chloro-3-fluoro-2-propoxy-; 5-Bromo-1-chloro-3-fluoro-2-propoxy-benzene
EINECS	Contact for details

Quality Control

Our 5-Bromo-1-Chloro-3-Fluoro-2-Propoxybenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.