Description

2-(2,6-Dimethylphenyl)-2,2-Difluoroacetic Acid is a high-value, synthetically versatile fluorinated aromatic building block. This compound is critical for advanced organic synthesis, particularly in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals where the introduction of a difluoroacetic acid moiety can significantly alter biological activity and metabolic stability. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating next-generation compounds.

Application

• Pharmaceutical Intermediate: Key synthon for the research and development of new drug candidates, especially in medicinal chemistry programs targeting enzyme inhibition.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and pesticides, where the difluoromethyl group enhances efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of fluorinated polymers and advanced organic materials with unique electronic or surface properties.
• Custom Synthesis and Contract Manufacturing: A vital starting material for fine chemical manufacturers offering bespoke synthesis services to global clients.
• Academic Research: Used in university and institutional labs for studying fluorination chemistry and reaction mechanisms.

Basic Information

Product Name	2-(2,6-Dimethylphenyl)-2,2-Difluoroacetic Acid
CAS No.	1820703-25-0
Molecular Formula	C10H10F2O2
Molecular Weight	200.18 g/mol
Synonyms	2,2-Difluoro-2-(2,6-dimethylphenyl)acetic Acid; α,α-Difluoro-2,6-dimethylphenylacetic Acid; (2,6-Dimethylphenyl)difluoroacetic Acid; 2-(2,6-Dimethylphenyl)-2,2-difluoroethanoic Acid; 2,6-Dimethyl-α,α-difluorophenylacetic Acid; DFMPAA; Difluoro(o-xylyl)acetic Acid
EINECS	Contact for details

Quality Control

Every batch of 2-(2,6-Dimethylphenyl)-2,2-Difluoroacetic Acid is produced and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the precise requirements of your synthetic application. A detailed Certificate of Analysis (COA), including results from HPLC, NMR, and mass spectrometry, is supplied with each shipment to guarantee identity, purity, and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area. For long-term storage, temperatures between 2°C and 8°C are recommended. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.