Description

(R,Z)-4-((tert-Butyldimethylsilyl)Oxy)-N,n-Diphenylpent-2-Enamide is a high-purity, chiral synthetic intermediate featuring a protected hydroxyl group and an enamide moiety. This compound is critical for advanced pharmaceutical research and development, particularly in the synthesis of complex, biologically active molecules where stereochemical control is paramount. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for constructing sophisticated molecular architectures.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of novel active pharmaceutical ingredients (APIs), especially for targets requiring specific (R,Z) stereochemistry.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) and improve drug-like properties.
• Process Chemistry Development: Serves as a critical intermediate in scaling up synthetic routes for preclinical and clinical trial material production.
• Asymmetric Synthesis: Employed in catalytic asymmetric transformations and chiral pool syntheses due to its defined stereocenters and functional handles.
• Agrochemical Synthesis: A potential intermediate for creating chiral active ingredients in crop protection agents.
• Academic & Institutional R&D: Used in university and research institute laboratories for methodological development and the study of new organic reactions.

Basic Information

Item	Details
Product Name	(R,Z)-4-((tert-Butyldimethylsilyl)Oxy)-N,n-Diphenylpent-2-Enamide
CAS No.	1820030-49-6
Molecular Formula	C23H31NO2Si
Molecular Weight	381.59 g/mol
Synonyms	(4R)-4-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]-N,N-diphenyl-2-pentenamide; (R)-4-((tert-Butyldimethylsilyl)oxy)-N,N-diphenylpent-2-enamide; (R,Z)-TBDMS-protected pentenamide; 1820030-49-6; (R,Z)-4-(tert-Butyldimethylsiloxy)-N,N-diphenyl-2-pentenamide; (R,Z)-4-(TBDMSO)-N,N-diphenylpent-2-enamide; N,N-Diphenyl-4-[(tert-butyldimethylsilyl)oxy]-2-pentenamide, (4R)-
EINECS	Contact for details

Quality Control

Every batch of (R,Z)-4-((tert-Butyldimethylsilyl)Oxy)-N,n-Diphenylpent-2-Enamide is manufactured under strict quality management systems and undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. Our rigorous quality testing includes chiral HPLC to confirm stereochemical integrity and standard pharmacopeial methods where applicable. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting critical specifications. We support development and commercial projects requiring compliance with cGMP, ICH Q7, and other relevant regulatory guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is light-sensitive (store away from light) and may be sensitive to fluoride/strong alkali. Keep away from incompatible materials. For long-term storage under inert atmosphere, please contact us for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.