Description

Trifluoroacetic Acid CAS NO 1818843-17-2 is a highly versatile and potent fluorinated organic acid, valued for its strong acidity and excellent solvating properties. It serves as a critical reagent and solvent in advanced synthetic chemistry, enabling key transformations in the production of pharmaceuticals and specialty materials. This product is essential for research laboratories, pharmaceutical manufacturers, and agrochemical producers requiring a high-purity, reactive medium for peptide synthesis, deprotection reactions, and as a mobile phase component in analytical chromatography.

Application

• Pharmaceutical Synthesis: A key reagent for peptide coupling and as a deprotecting agent for Boc (tert-butoxycarbonyl) and other acid-labile protecting groups.
• Analytical Chemistry: Used as a volatile ion-pairing agent and mobile phase modifier in High-Performance Liquid Chromatography (HPLC) for separating complex mixtures, particularly peptides and proteins.
• Organic Synthesis & Catalysis: Employed as a strong acid catalyst in various organic reactions, including esterifications, rearrangements, and cyclizations.
• Polymer & Material Science: Acts as a solvent for polyamides and other high-performance polymers, and as an etching agent in microfabrication processes.
• Agrochemical Intermediates: Used in the synthesis of fluorinated pesticides and herbicides, leveraging its ability to introduce trifluoromethyl groups.
• Biochemistry & Proteomics: Utilized in protein digestion and sequencing workflows due to its effectiveness in denaturing proteins.

Basic Information

Item	Detail
Product Name	Trifluoroacetic Acid
CAS No.	1818843-17-2
Molecular Formula	C2HF3O2
Molecular Weight	114.02 g/mol
Synonyms	Trifluoroethanoic Acid; TFA; Perfluoroacetic Acid; 2,2,2-Trifluoroacetic Acid; Acetic Acid, Trifluoro-; CF3COOH; NSC 77379; UN 2699
EINECS	Contact for details

Quality Control

Our Trifluoroacetic Acid is manufactured under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including assay by titration, impurity profiling via gas chromatography (GC), and verification of key physical properties to ensure it meets the high standards required for pharmaceutical and research applications. A Certificate of Analysis (COA) detailing purity, identity, and specific test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat sources and incompatible materials such as strong bases and oxidizing agents. Due to its highly volatile and corrosive nature, containers must be kept upright and securely sealed. Recommended storage temperature is 2-25°C.

Specification

Item	Specification
Appearance	Clear, colorless liquid
Identification (IR)	Conforms
Assay (GC)	≥ 99.5%
Water Content (Karl Fischer)	≤ 0.05%
Residue on Evaporation	≤ 0.005%
Chloride (Cl)	≤ 10 ppm
Sulfate (SO4)	≤ 10 ppm
Heavy Metals (as Pb)	≤ 5 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.