Description

Propargyl-Peg7-Acid CAS NO 1818294-28-8 is a high-purity, heterobifunctional polyethylene glycol (PEG) linker featuring a terminal propargyl group for copper-catalyzed azide-alkyne cycloaddition (CuAAC) click chemistry and a carboxylic acid group for standard amide coupling. This compound is essential for creating stable, hydrophilic spacers in bioconjugation, enabling the precise attachment of biomolecules, drugs, or imaging agents. It is primarily needed by researchers and manufacturers in pharmaceutical development, biotech, and advanced materials science for constructing antibody-drug conjugates (ADCs), PEGylated therapeutics, and functionalized nanoparticles.

Application

• Bioconjugation & ADC Development: Serves as a key linker for attaching cytotoxic payloads to monoclonal antibodies via click chemistry, forming stable triazole linkages.
• PEGylation Reagent: Used to introduce hydrophilic PEG chains onto peptides, proteins, or small molecule drugs to improve solubility, stability, and circulation half-life.
• Surface Functionalization: Enables the covalent modification of nanoparticles, quantum dots, or biosensor surfaces with bioactive ligands for targeted delivery and diagnostics.
• Polymer & Materials Science: Acts as a building block for synthesizing functionalized hydrogels, smart polymers, and dendrimers with tailored chemical handles.
• Probe & Diagnostic Agent Synthesis: Facilitates the creation of fluorescent, radioactive, or MRI contrast agent conjugates for bioimaging and diagnostic applications.
• Chemical Biology Tool: Employed in activity-based protein profiling (ABPP) and the synthesis of chemical probes to study enzyme function and protein-protein interactions.

Basic Information

Product Name	Propargyl-Peg7-Acid
CAS No.	1818294-28-8
Molecular Formula	C22H40O11
Molecular Weight	480.55 g/mol
Synonyms	Propargyl-PEG7-acid; 2,5,8,11,14,17,20-Heptaoxadocosan-22-ynoic acid; Propargyl-O-CH2CH2-(OCH2CH2)6-O-CH2COOH; Propargyl-PEG7-COOH; α-Propargyl-ω-carboxy heptaethylene glycol; 22-Prop-2-yn-1-yloxy-3,6,9,12,15,18,21-heptaoxatricosanoic acid; Propargyl-PEG7-propionic acid; Heterobifunctional PEG Alkyne-Acid
EINECS	Contact for details

Quality Control

Our Propargyl-Peg7-Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C. Under these conditions, the product is stable for at least 24 months. The material is hygroscopic; allow the vial to equilibrate to room temperature in a desiccator before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay	≥ 90% (by NMR)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.