Description

2,5-Difluoro-4-Hydroxyphenylboronic Acid Pinacol Ester is a high-purity, advanced pharmaceutical intermediate and versatile building block in organic synthesis. Its value lies in its role as a protected boronic acid derivative, offering enhanced stability and solubility for demanding cross-coupling reactions, particularly the Suzuki-Miyaura reaction. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries developing novel fluorinated compounds and complex organic molecules.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of active pharmaceutical ingredients (APIs), especially those containing difluorophenol and arylboronate motifs.
• Suzuki-Miyaura Cross-Coupling: Serves as a stable, reactive partner for constructing biaryl and heterobiaryl structures in drug discovery and material science.
• Agrochemical Synthesis: Used in the research and development of new-generation fluorinated pesticides and herbicides.
• Liquid Crystal & OLED Material Precursor: Employed in the synthesis of fluorinated organic electronic materials for displays and lighting.
• Chemical Biology & Probe Development: Utilized as a versatile handle for bioconjugation and the creation of molecular probes and sensors.
• Polymer Chemistry: Acts as a monomer or functionalization agent for creating specialty polymers with tailored properties.

Basic Information

Product Name	2,5-Difluoro-4-Hydroxyphenylboronic Acid Pinacol Ester
CAS No.	1817835-85-0
Molecular Formula	C₁₂H₁₅BF₂O₃
Molecular Weight	256.06 g/mol
Synonyms	2,5-Difluoro-4-hydroxyphenylboronic acid pinacol ester; 4-Hydroxy-2,5-difluorophenylboronic acid pinacol ester; (2,5-Difluoro-4-hydroxyphenyl)boronic acid pinacol ester; 2,5-Difluoro-4-hydroxybenzeneboronic acid pinacol ester; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,5-difluorophenol; PINACOL (2,5-DIFLUORO-4-HYDROXYPHENYL)BORONATE
EINECS	Contact for details

Quality Control

Our 2,5-Difluoro-4-Hydroxyphenylboronic Acid Pinacol Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your R&D and quality assurance processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Assay	≥95.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.