Description

1,1,1-Trifluoroethyl-Peg5-Propargyl is a specialized bifunctional polyethylene glycol (PEG) derivative designed for advanced bioconjugation and materials science applications. This compound is engineered to provide a versatile linker, combining the solubility and biocompatibility of a PEG spacer with the unique reactivity of both a propargyl and a 1,1,1-trifluoroethyl group. It is a critical reagent for researchers and manufacturers in the pharmaceutical and biotechnology sectors who require precise, stable, and high-performance conjugation strategies. The product is supplied under stringent quality control to ensure batch-to-batch consistency for sensitive R&D and production workflows.

Application

• Bioconjugation Linker: Acts as a heterobifunctional crosslinker for attaching biomolecules (e.g., peptides, proteins, oligonucleotides) to surfaces, nanoparticles, or other molecules via click chemistry (CuAAC) and other reactions.
• ADC (Antibody-Drug Conjugate) Development: Serves as a key component in the synthesis of linker-payload constructs, leveraging the PEG chain to improve solubility and pharmacokinetic properties of the therapeutic conjugate.
• Polymer and Materials Modification: Used to introduce functional handles (propargyl groups) into polymers, hydrogels, and coatings for subsequent functionalization or to impart fluorinated characteristics for altered surface properties.
• Diagnostic Reagent Synthesis: Employed in the creation of labeled probes and contrast agents for imaging and diagnostic assays, where the PEG spacer reduces non-specific binding.
• Solid-Phase Peptide Synthesis (SPPS): Can be utilized as a soluble support or as a building block to introduce PEGylation and fluorinated tags during peptide synthesis.
• Chemical Biology Tool: A valuable reagent for probing biological systems and developing new chemical methodologies that require orthogonal reactivity and enhanced stability in aqueous environments.

Basic Information

Product Name	1,1,1-Trifluoroethyl-Peg5-Propargyl
CAS No.	1817735-37-7
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Propargyl-PEG5-CH2CF3; 2,5,8,11,14-Pentaoxaheptadec-16-yn-1-ol, 17,17,17-trifluoro-16-methyl-; 1,1,1-Trifluoro-2-(2-(2-(2-(2-(prop-2-yn-1-yloxy)ethoxy)ethoxy)ethoxy)ethoxy)ethane; Trifluoroethyl-PEG5-alkyne; Alkyne-PEG5-CH2CF3; CF3-PEG5-Propargyl; Heterobifunctional PEG Alkyne Trifluoroethyl
EINECS	Contact for details

Quality Control

Every batch of 1,1,1-Trifluoroethyl-Peg5-Propargyl undergoes rigorous analytical testing to ensure it meets the high-purity standards required for research and pharmaceutical applications. Our quality assurance protocols include advanced chromatographic and spectroscopic methods to verify identity, purity, and functional group integrity. A comprehensive Certificate of Analysis (COA) detailing purity (typically by HPLC/NMR), appearance, and moisture content is provided with each shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or oil
Identification (NMR/IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.