Description

(Leu116)-Prepro-Neuromedin U (104-136) (Human) CAS NO 1816939-42-0 is a synthetic peptide fragment corresponding to a specific region of the human prepro-neuromedin U protein, incorporating a leucine substitution at position 116. This compound is a critical research-grade biochemical tool for studying the neuromedin U (NMU) signaling system, which plays significant roles in energy homeostasis, stress response, and gastrointestinal function. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies engaged in neuroendocrine research, peptide hormone studies, and drug discovery programs targeting NMU receptors.

Application

• Biochemical Research: Used as a reference standard and active agent in studies investigating the structure-activity relationships (SAR) of neuromedin U and its receptor interactions.
• Drug Discovery & Development: Serves as a key intermediate or pharmacological tool in screening assays and preclinical research for developing therapeutics targeting metabolic disorders or central nervous system conditions.
• Neuroscience Studies: Applied in experimental models to elucidate the physiological and pathophysiological roles of neuromedin U in appetite regulation, stress, and circadian rhythms.
• Antibody Production & Immunoassays: Acts as an immunogen for generating specific antibodies or as a calibrator in immunoassay development (e.g., ELISA) for detecting NMU-related peptides.
• Cell Signaling & Molecular Biology: Utilized in cell-based assays to activate NMU receptors and study downstream signal transduction pathways.

Basic Information

Product Name	(Leu116)-Prepro-Neuromedin U (104-136) (Human)
CAS No.	1816939-42-0
Molecular Formula	C170H277N51O48S
Molecular Weight	3790.4 g/mol (monoisotopic)
Synonyms	Neuromedin U-33 (Human) Leu116 analog; NMU-33 (104-136), Leu116; H-Phe-Leu-Phe-Arg-Pro-Arg-Asn-NH2 (Sequence variant); PrepronmU (104-136) [Leu116]; Synthetic Neuromedin U Peptide Fragment; CAS 1816939-42-0; Leu116-NMU-33 (human); NmU (104-136) analog
EINECS	Contact for details

Quality Control

This high-purity peptide is manufactured under controlled conditions and undergoes rigorous analytical characterization. Quality is assured through multiple orthogonal methods, including reverse-phase HPLC for purity assessment and mass spectrometry (MS) for identity confirmation. Our products comply with stringent in-house specifications for research use. A comprehensive Certificate of Analysis (COA), detailing purity, content, and analytical data, is provided with each batch and available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. Aliquot into smaller working quantities to minimize freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Molecular weight confirmed by ESI-MS or MALDI-TOF
Purity (HPLC)	≥ 95% (at 214 nm or 280 nm)
Peptide Content	≥ 80% (by weight)
Amino Acid Analysis	Composition agrees with theoretical values (±10%)
Solubility	Soluble in water, dilute acetic acid, or suitable aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.