Description

Biotinyl-(Gln1)-Gastrin I (Human) is a biotinylated derivative of the human gastrin I peptide, a key hormone involved in gastric acid secretion. This modified peptide is a critical research-grade biochemical tool, offering enhanced detection and isolation capabilities due to the high-affinity biotin-streptavidin interaction. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and diagnostic developers in the fields of endocrinology, gastroenterology, and oncology research. The compound, identified by CAS NO 1815618-03-1, enables advanced studies on gastrin receptor binding, signaling pathways, and the development of targeted assays.

Application

• Biochemical Research: Used as a high-affinity probe for studying gastrin/CCK-B receptor binding kinetics, internalization, and downstream signaling cascades in vitro.
• Diagnostic Assay Development: Serves as a critical capture or detection reagent in the development of ELISA, Western blot, and other immunoassays for gastrin-related studies.
• Affinity Purification: Facilitates the isolation and purification of gastrin-binding proteins or receptor complexes using streptavidin-coated beads or columns.
• Cell Imaging and Localization: Employed in fluorescence microscopy and flow cytometry applications when conjugated with streptavidin-linked fluorophores for cellular receptor visualization.
• Drug Discovery Screening: Acts as a tool compound in high-throughput screening (HTS) platforms to identify and characterize novel gastrin receptor antagonists or agonists.
• Proteomics and Biomarker Research: Used in pull-down experiments and mass spectrometry to identify novel interacting partners in gastrin-mediated pathways.

Basic Information

Product Name	Biotinyl-(Gln1)-Gastrin I (Human)
CAS No.	1815618-03-1
Molecular Formula	C98H147N25O30S
Molecular Weight	~2187.5 g/mol
Synonyms	Biotin-Gastrin I (human); Biotinylated Gastrin I; Biotinyl-Gastrin I; Gastrin I (human), Biotinyl-(Gln1)-; Biotin-LC-Gastrin I; pGlu-Gln-Gly-Pro-Trp-Leu-(Glu)5-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2 (Biotinylated); Biotin-XX-Gastrin I; Research Gastrin Peptide
EINECS	Contact for details

Quality Control

Our Biotinyl-(Gln1)-Gastrin I (Human) is manufactured under strict quality systems suitable for research applications. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Certificates of Analysis (COA) are provided, detailing results from HPLC for purity, Mass Spectrometry (MS) for identity confirmation, and other relevant assays. We support compliance with relevant research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). For long-term storage, it is recommended to store the lyophilized powder desiccated at -20°C. Reconstituted solutions should be aliquoted and stored at -20°C or -80°C to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO, or dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.