Description

1,3,2-Dioxaborolane, 4,4,5,5-Tetramethyl-2-[4-[[3-(Trifluoromethyl)Phenyl]Methoxy]Phenyl]- is a high-value, functionalized boronic ester derivative, serving as a critical synthetic intermediate in advanced organic synthesis. Its core value lies in enabling efficient cross-coupling reactions, particularly the Suzuki-Miyaura reaction, to construct complex biaryl architectures with high precision and yield. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries who require reliable, high-purity building blocks for drug discovery and specialty chemical development.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), especially those containing trifluoromethylphenyl and biaryl motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides that require specific aryl-aryl couplings.
• Materials Science Research: Precursor for creating organic electronic materials, such as those used in OLEDs (Organic Light-Emitting Diodes) and OFETs (Organic Field-Effect Transistors), due to its conjugated system.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing specialized ligands and organometallic catalysts used in asymmetric synthesis.
• Chemical Biology Probes: Utilized in the development of molecular probes and tags for studying biological processes and protein interactions.
• Custom Synthesis and Contract Manufacturing: Supplied to CROs (Contract Research Organizations) and CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthetic projects.

Basic Information

Product Name	1,3,2-Dioxaborolane, 4,4,5,5-Tetramethyl-2-[4-[[3-(Trifluoromethyl)Phenyl]Methoxy]Phenyl]-
CAS No.	1813554-41-4
Molecular Formula	C20H22BF3O3
Molecular Weight	378.20 g/mol
Synonyms	4,4,5,5-Tetramethyl-2-[4-[[3-(trifluoromethyl)phenoxy]phenyl]-1,3,2-dioxaborolane; 2-(4-((3-(Trifluoromethyl)phenoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; [4-[[3-(Trifluoromethyl)Phenyl]Methoxy]Phenyl]boronic Acid Pinacol Ester; 4-((3-(Trifluoromethyl)phenoxy)phenylboronic Acid Pinacol Ester; Pinacol [4-[[3-(Trifluoromethyl)Phenyl]Methoxy]Phenyl]boronate; (4-((3-(Trifluoromethyl)phenoxy)phenyl)boronic Acid Pinacol Ester; CAS 1813554-41-4
EINECS	Contact for details

Quality Control

Our 1,3,2-Dioxaborolane, 4,4,5,5-Tetramethyl-2-[4-[[3-(Trifluoromethyl)Phenyl]Methoxy]Phenyl]- is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR (1H, 13C, 19F, 11B), and GC/MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting all critical parameters. Our quality commitment supports applications requiring GMP-grade intermediates and materials for regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong acids and strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.