Description

4-Nitro-2-(Trifluoromethyl)Phenylboronic Acid, Pinacol Ester is a high-value, organoboron building block crucial for modern synthetic chemistry. This compound matters as a protected boronic acid derivative, offering enhanced stability and handling characteristics for complex cross-coupling reactions. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing novel molecules containing the nitro and trifluoromethyl pharmacophores.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for the palladium-catalyzed formation of biaryl and heterobiaryl bonds, essential in pharmaceutical intermediate synthesis.
• Pharmaceutical Intermediate: Used in the research and development of active pharmaceutical ingredients (APIs), particularly those targeting CNS disorders, inflammation, and oncology.
• Agrochemical Synthesis: Serves as a building block for novel herbicides, fungicides, and insecticides, leveraging the biological activity of the nitro and trifluoromethyl groups.
• Material Science Research: Employed in the synthesis of advanced organic materials, such as organic light-emitting diodes (OLEDs) and liquid crystals.
• Chemical Biology & Probe Development: Utilized for creating molecular probes and tags for studying biological systems and enzyme activity.
• Process Chemistry & Scale-up: The pinacol ester form provides superior stability for handling in kilogram-scale manufacturing processes under GMP conditions.

Basic Information

Product Name	4-Nitro-2-(Trifluoromethyl)Phenylboronic Acid, Pinacol Ester
CAS No.	1810767-17-9
Molecular Formula	C₁₃H₁₅BF₃NO₄
Molecular Weight	329.07 g/mol
Synonyms	4-Nitro-2-(trifluoromethyl)benzeneboronic acid pinacol ester; 2-(Trifluoromethyl)-4-nitrophenylboronic acid pinacol ester; (4-Nitro-2-(trifluoromethyl)phenyl)boronic acid pinacol ester; Pinacol [4-nitro-2-(trifluoromethyl)phenyl]boronate; B-[4-Nitro-2-(trifluoromethyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4,4,5,5-Tetramethyl-2-[4-nitro-2-(trifluoromethyl)phenyl]-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our 4-Nitro-2-(Trifluoromethyl)Phenylboronic Acid, Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our commitment to reliable supply and documentation traceability supports your regulatory and process development needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at 2-8°C or as specified on the label. Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.