Description

1-(4-Bromo-2-Fluorobenzoyl)-3,3-Dimethylazetidine is a high-purity, advanced pharmaceutical intermediate featuring a unique azetidine core functionalized with halogenated benzoyl groups. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel drug candidates targeting a range of therapeutic areas. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries seeking to incorporate constrained, three-dimensional scaffolds into their molecular designs.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) for preclinical and clinical development.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore new chemical space and optimize drug-like properties.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential linker or warhead component in the design of targeted protein degradation therapeutics.
• Covalent Inhibitor Synthesis: The reactive halogen and carbonyl groups make it a candidate for developing covalent binding molecules.
• Chemical Biology Probes: Utilized to create tool compounds for investigating biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: Supplied for bespoke synthesis projects requiring specialized, high-value intermediates.

Basic Information

Product Name	1-(4-Bromo-2-Fluorobenzoyl)-3,3-Dimethylazetidine
CAS No.	1810070-16-6
Molecular Formula	C12H13BrFNO
Molecular Weight	286.14 g/mol
Synonyms	3,3-Dimethylazetidine-1-(4'-bromo-2'-fluorobenzoyl); 4-Bromo-2-fluoro-1-[1-(3,3-dimethylazetidinyl)]methanone; 1-(4-Bromo-2-fluorobenzoyl)-3,3-dimethylazetidine; (4-Bromo-2-fluorophenyl)(3,3-dimethylazetidin-1-yl)methanone; 3,3-Dimethyl-1-(4-bromo-2-fluorobenzoyl)azetidine; Azetidine, 1-(4-bromo-2-fluorobenzoyl)-3,3-dimethyl-; 1810070-16-6
EINECS	Contact for details

Quality Control

Our 1-(4-Bromo-2-Fluorobenzoyl)-3,3-Dimethylazetidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical quality attributes. Our production adheres to cGMP guidelines for pharmaceutical intermediates, ensuring reliability for your most demanding research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container sealed to protect from moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.