Description

5,8-Difluorochroman-4-Amine Hydrochloride is a high-purity fluorinated chiral building block and intermediate of significant interest in advanced organic synthesis. Its value lies in the strategic incorporation of fluorine atoms and the chroman scaffold, which are pivotal for modulating the biological activity, metabolic stability, and physicochemical properties of target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, serving as a key precursor for novel active ingredients.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the research and development of new drug candidates, particularly in central nervous system (CNS) and cardiovascular therapeutic areas.
• Agrochemical Synthesis: Used in the creation of advanced pesticides and herbicides, where the difluoro motif enhances lipophilicity and target binding.
• Chemical Biology Probe Development: Serves as a scaffold for building molecular probes to study enzyme function and receptor interactions.
• Material Science Research: Investigated as a monomer or precursor for specialty polymers with unique optical or electronic properties.
• Academic & Contract Research: Employed in universities and CROs for methodological studies in asymmetric synthesis and fluorine chemistry.

Basic Information

Product Name	5,8-Difluorochroman-4-Amine Hydrochloride
CAS No.	1810070-13-3
Molecular Formula	C9H8F2NO.ClH
Molecular Weight	219.62 g/mol (Free base)
Synonyms	4-Amino-5,8-difluorochroman hydrochloride; 5,8-Difluoro-3,4-dihydro-2H-1-benzopyran-4-amine hydrochloride; Chroman-4-amine, 5,8-difluoro-, hydrochloride; 5,8-Difluorochroman-4-amine HCl; 5,8-Difluoro-3,4-dihydro-2H-chromen-4-amine hydrochloride
EINECS	Contact for details

Quality Control

Our 5,8-Difluorochroman-4-Amine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation by NMR and MS, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, and custom purity grades are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.