Description

Bis[3,5-Bis(trifluoromethyl)phenyl][3,6-dimethoxy-2',6'-bis(1-methylethoxy)[1,1'-biphenyl]-2-yl]phosphine is a sophisticated, electron-rich monodentate phosphine ligand designed for high-performance catalysis. Its value lies in its ability to facilitate challenging cross-coupling and other transition metal-catalyzed reactions, offering superior stability and reactivity compared to simpler phosphines. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require precise control over complex synthetic pathways. The CAS number for this compound is 1810068-31-5.

Application

• Pharmaceutical Intermediate Synthesis: As a key ligand in palladium-catalyzed cross-coupling reactions (e.g., Suzuki-Miyaura, Buchwald-Hartwig amination) for constructing complex drug molecules and APIs.
• Agrochemical Research & Development: Enabling the synthesis of novel active ingredients through efficient carbon-heteroatom bond formation.
• Advanced Material Fabrication: Catalyzing polymerization and polymer modification reactions to create specialized polymers with tailored properties.
• Fine Chemical Production: Used in the synthesis of high-value, structurally complex specialty chemicals and flavors/fragrances.
• Academic & Industrial Catalysis Research: Serving as a premium ligand for developing new catalytic methodologies and optimizing reaction conditions.
• Electronics Chemical Manufacturing: Potential application in the synthesis of organic semiconductors and molecular electronic components.

Basic Information

Product Name	Bis[3,5-Bis(trifluoromethyl)phenyl][3,6-dimethoxy-2',6'-bis(1-methylethoxy)[1,1'-biphenyl]-2-yl]phosphine
CAS No.	1810068-31-5
Molecular Formula	C44H38F12O4P
Molecular Weight	880.72 g/mol
Synonyms	Bis(3,5-bis(trifluoromethyl)phenyl)(2',6'-diisopropoxy-3,6-dimethoxy-[1,1'-biphenyl]-2-yl)phosphine; (2',6'-Diisopropoxy-3,6-dimethoxy-[1,1'-biphenyl]-2-yl)bis(3,5-bis(trifluoromethyl)phenyl)phosphine; BippyPhos; BippyPhos Ligand; [3,6-Dimethoxy-2',6'-bis(1-methylethoxy)[1,1'-biphenyl]-2-yl]bis[3,5-bis(trifluoromethyl)phenyl]phosphine
EINECS	Contact for details

Quality Control

Our Bis[3,5-Bis(trifluoromethyl)phenyl][3,6-dimethoxy-2',6'-bis(1-methylethoxy)[1,1'-biphenyl]-2-yl]phosphine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR (¹H, ³¹P, ¹⁹F), and elemental analysis, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We adhere to cGMP standards where applicable to support our clients in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. Due to its sensitivity to oxidation and light, prolonged exposure to air or ambient light should be avoided. Keep the container sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
³¹P NMR Purity	Conforms
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.