Description

2'-(Bis(3,5-Bis(Trifluoromethyl)Phenyl)Phosphino)-3',6'-Dimethoxy-N2,N2,N6,N6-Tetramethyl-[1,1'-Biphenyl]-2,6-Diamine is a sophisticated, electron-deficient phosphine ligand designed for high-performance catalysis. This compound matters because it enables challenging cross-coupling and hydrogenation reactions under mild conditions, offering superior selectivity and activity for fine chemical synthesis. It is primarily needed by R&D chemists and process engineers in the pharmaceutical and advanced materials sectors for developing novel active pharmaceutical ingredients (APIs) and specialty polymers. The CAS number for this product is 1810068-30-4.

Application

• Pharmaceutical Intermediate Synthesis: As a key ligand in palladium-catalyzed cross-coupling reactions (e.g., Suzuki-Miyaura, Buchwald-Hartwig amination) for constructing complex drug molecules.
• Asymmetric Hydrogenation Catalysis: Employed in the synthesis of chiral intermediates for active pharmaceutical ingredients (APIs), where high enantioselectivity is critical.
• Advanced Material Research: Facilitating the polymerization and functionalization of novel organic electronic materials and specialty polymers.
• Process Chemistry & Scale-Up: Enabling more efficient and robust catalytic processes for the commercial-scale production of fine chemicals.
• Academic & Industrial R&D: Serving as a valuable tool for methodology development in organic synthesis and catalysis research.
• Ligand for Specialty Catalysts: Used to prepare pre-formed metal complexes for specific, high-value transformations.

Basic Information

Product Name	2'-(Bis(3,5-Bis(Trifluoromethyl)Phenyl)Phosphino)-3',6'-Dimethoxy-N2,N2,N6,N6-Tetramethyl-[1,1'-Biphenyl]-2,6-Diamine
CAS No.	1810068-30-4
Molecular Formula	C42H35F12N2O2P
Molecular Weight	866.71 g/mol
Synonyms	BrettPhos-Type Ligand; XPhos-Type Advanced Ligand; (3,6-Dimethoxy-2',4',6'-triisopropyl-[1,1'-biphenyl]-2-yl)dicyclohexylphosphine Analog; Buchwald Ligand Derivative; Biarylphosphine Ligand; Electron-Deficient Phosphine; 2-Dicyclohexylphosphino-2',4',6'-triisopropylbiphenyl Related Ligand; Tetramethyl-BrettPhos
EINECS	Contact for details

Quality Control

Our 2'-(Bis(3,5-Bis(Trifluoromethyl)Phenyl)Phosphino)-3',6'-Dimethoxy-N2,N2,N6,N6-Tetramethyl-[1,1'-Biphenyl]-2,6-Diamine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR (1H, 13C, 31P), HPLC, and elemental analysis, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We adhere to cGMP standards where applicable to support our clients in regulated pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store the product in a freezer at -20°C to -10°C under an inert atmosphere (argon or nitrogen), as it is easily oxidized. Allow the sealed container to reach room temperature before opening to prevent moisture condensation. Keep away from strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.