Description

(R)-n-((3-Methylpyridin-2-Yl)Methyl)-7′-Di(3,5-Di-tert-Butylphenyl)Phosphino-1,1′-Spirobiindanyl-7-Amine CAS NO 1809609-53-7 is a sophisticated, chiral monophosphine ligand designed for high-performance asymmetric catalysis. This compound matters because it provides exceptional stereoselectivity and stability in demanding transition-metal-catalyzed reactions, enabling the synthesis of complex chiral molecules. It is primarily needed by R&D chemists and process engineers in the pharmaceutical, agrochemical, and fine chemical industries for developing new active ingredients and optimizing synthetic routes.

Application

• As a key chiral ligand in asymmetric hydrogenation reactions for pharmaceutical intermediate synthesis.
• For enantioselective C-C bond formation processes, including cross-coupling and allylic substitution.
• In the catalytic asymmetric synthesis of amino acids, amines, and alcohols with high enantiomeric excess (ee).
• As a specialty catalyst component in the production of advanced agrochemicals and flavors/fragrances.
• For academic and industrial research in developing new catalytic methodologies.
• In process chemistry for scaling up the manufacture of chiral active pharmaceutical ingredients (APIs).

Basic Information

Product Name	(R)-n-((3-Methylpyridin-2-Yl)Methyl)-7′-Di(3,5-Di-tert-Butylphenyl)Phosphino-1,1′-Spirobiindanyl-7-Amine
CAS No.	1809609-53-7
Molecular Formula	C55H65N2P
Molecular Weight	785.09 g/mol
Synonyms	(R)-SIPHOS-PE; (R)-7′-Bis(3,5-di-tert-butylphenyl)phosphino-1,1′-spirobiindane-7-amine, N-[(3-methyl-2-pyridinyl)methyl]-; (R)-DTBM-SIPHOS-PE; (R)-N-((3-Methylpyridin-2-yl)methyl)-7′-[bis(3,5-di-tert-butylphenyl)phosphino]-1,1′-spirobiindane-7-amine; (R)-SIPHOS-PE Ligand; Chiral SIPHOS-PE derivative; Asymmetric monophosphine ligand; (R)-7′-[Bis(3,5-di-tert-butylphenyl)phosphino]-N-[(3-methylpyridin-2-yl)methyl]-1,1′-spirobiindane-7-amine
EINECS	Contact for details

Quality Control

Our (R)-n-((3-Methylpyridin-2-Yl)Methyl)-7′-Di(3,5-Di-tert-Butylphenyl)Phosphino-1,1′-Spirobiindanyl-7-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and NMR for structural confirmation, to ensure consistent high performance in catalytic applications. Certificates of Analysis (COA) with detailed specifications are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store the product under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, the container should be sealed immediately after use to minimize exposure to air.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.