Description

(R)-(+)-7-[n-(2-Benzylthio)Ethylamino]-7'-[Bis(3,5-Di-T-Butylphenyl)Phosphino]-2,2',3,3'-Tetrahydro-1,1'-Spirobindane, 97+% (>99% Ee) [(R)-Dtb-Spirosap-Bn] is a high-purity, chiral phosphine ligand designed for advanced asymmetric catalysis. This compound matters because it provides exceptional enantioselectivity and stability, enabling the efficient synthesis of complex chiral molecules critical for pharmaceutical and fine chemical development. It is primarily needed by R&D chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries for applications such as asymmetric hydrogenation and cross-coupling reactions.

Application

• Asymmetric Hydrogenation Catalysis: A key ligand for the enantioselective reduction of prochiral olefins, ketones, and imines in pharmaceutical intermediate synthesis.
• Cross-Coupling Reactions: Employed in asymmetric Suzuki-Miyaura, Heck, and other C-C bond-forming reactions to construct chiral centers.
• Pharmaceutical Intermediate Manufacturing: Enables the production of high-value, single-enantiomer active pharmaceutical ingredients (APIs) for drugs targeting CNS disorders, cardiovascular diseases, and oncology.
• Agrochemical Synthesis: Used in the development of chiral pesticides and herbicides with improved efficacy and environmental profiles.
• Fine Chemical and Fragrance Production: Facilitates the creation of enantiomerically pure flavors, fragrances, and advanced material precursors.
• Academic and Industrial R&D: A valuable tool for methodology development and exploring new catalytic transformations in academic and corporate research laboratories.

Basic Information

Item	Details
Product Name	(R)-(+)-7-[n-(2-Benzylthio)Ethylamino]-7'-[Bis(3,5-Di-T-Butylphenyl)Phosphino]-2,2',3,3'-Tetrahydro-1,1'-Spirobindane, 97+% (>99% Ee) [(R)-Dtb-Spirosap-Bn]
CAS No.	1809609-52-6
Molecular Formula	C55H70NPS2
Molecular Weight	840.26 g/mol
Synonyms	(R)-DTB-SpiroSAP-Bn; (R)-Dtb-Spirosap-Bn; (R)-7-[N-(2-Benzylthio)ethylamino]-7'-[bis(3,5-di-tert-butylphenyl)phosphino]-2,2',3,3'-tetrahydro-1,1'-spirobiindane; (R)-Spiro-SAP-Bn; (R)-Dtb-SpiroSAP-Bn; (R)-SpiroSAP-Bn Ligand; (R)-Dtb-Spirosap-Bn Ligand; (R)-Dtb-SpiroSAP-Bn Phosphine Ligand
EINECS	Contact for details

Quality Control

Our (R)-Dtb-Spirosap-Bn is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes rigorous analytical testing, including HPLC for chemical purity (≥97%) and chiral HPLC for enantiomeric excess (≥99% ee). Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. This material is strictly light-sensitive (protect from all light exposure) and easily oxidized (store under inert atmosphere). For long-term stability, store under an inert atmosphere (argon or nitrogen) at 2-8°C. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97%
Enantiomeric Excess (Chiral HPLC)	≥ 99% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.