Description

(R)-(+)-7-[n-(2-Phenylthio)Ethylamino]-7'-[Bis(3,5-Di-T-Butylphenyl)Phosphino]-2,2',3,3'-Tetrahydro-1,1'-Spirobindane CAS NO 1809609-38-8 is a sophisticated chiral phosphine ligand designed for advanced asymmetric catalysis. This compound is engineered to provide exceptional stereoselectivity and catalytic efficiency in complex synthetic transformations, making it a critical tool for high-value chemical synthesis. It is primarily utilized by research institutions and industrial R&D departments in the pharmaceutical and fine chemical sectors for developing novel active ingredients and complex intermediates.

Application

• Asymmetric Hydrogenation: A key ligand for the enantioselective reduction of prochiral olefins, ketones, and imines in pharmaceutical intermediate synthesis.
• Cross-Coupling Reactions: Facilitates challenging C-C and C-X bond-forming reactions with high selectivity, useful for constructing complex molecular architectures.
• Pharmaceutical Process Development: Enables the scalable, stereocontrolled synthesis of chiral active pharmaceutical ingredients (APIs) and their precursors.
• Fine Chemical & Specialty Material Synthesis: Applied in the production of high-performance materials, agrochemicals, and flavors & fragrances requiring precise chirality.
• Academic & Industrial Research: Serves as a valuable reagent for methodology development in organometallic chemistry and catalysis research.
• Catalyst Screening Libraries: Used as a component in high-throughput screening for discovering new catalytic systems.

Basic Information

Product Name	(R)-(+)-7-[n-(2-Phenylthio)Ethylamino]-7'-[Bis(3,5-Di-T-Butylphenyl)Phosphino]-2,2',3,3'-Tetrahydro-1,1'-Spirobindane
CAS No.	1809609-38-8
Molecular Formula	C55H70NPS2
Molecular Weight	840.26 g/mol
Synonyms	(R)-SpiroBIPHEP-Thioethylamine Phosphine Ligand; (R)-(+)-SpiroBIPHEP-SEtNH2; (R)-7-(2-(Phenylthio)ethylamino)-7'-bis(3,5-di-tert-butylphenyl)phosphino-2,2',3,3'-tetrahydro-1,1'-spirobiindane; (R)-SEtNH2-SpiroBIPHEP; CAS 1809609-38-8; Chiral Spiro Phosphine-Amine Ligand; Asymmetric Hydrogenation Ligand
EINECS	Contact for details

Quality Control

Our production of this high-value chiral ligand adheres to strict quality protocols to ensure batch-to-batch consistency and optimal catalytic performance. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and chiral analysis to confirm identity, high chemical purity, and enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C or as specified on the label. This compound is easily oxidized and light-sensitive; prolonged exposure to air, moisture, or light should be avoided to maintain stability and catalytic activity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.