Description

Memantine n-B-D-Glucuronide is a key glucuronide metabolite of the NMDA receptor antagonist memantine, essential for advanced pharmaceutical research and development. This high-purity reference standard is critical for conducting precise pharmacokinetic, metabolic, and bioanalytical studies. It is primarily utilized by pharmaceutical companies, contract research organizations (CROs), and academic institutions focused on neurology and drug metabolism.

Application

• Pharmaceutical Reference Standard: Serves as a certified standard for the quantification of memantine and its metabolites in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used to investigate the metabolic pathways, clearance rates, and bioavailability of memantine.
• Bioanalytical Method Development: Essential for developing and validating sensitive HPLC-MS/MS or LC-MS methods for therapeutic drug monitoring.
• Preclinical and Clinical Research: Supports toxicology studies and clinical trials to understand the safety and efficacy profile of memantine-based therapies.
• Impurity Profiling: Employed as a known impurity or degradation product to ensure the purity and stability of memantine drug substances and products.
• Regulatory Submissions: Provides necessary data for filings with agencies like the FDA and EMA.

Basic Information

Product Name	Memantine n-B-D-Glucuronide
CAS No.	1809031-06-8
Molecular Formula	C23H39NO8 • (Counterion)
Molecular Weight	Contact for details
Synonyms	Memantine N-β-D-Glucuronide; Memantine Glucuronide; 1-Amino-3,5-dimethyladamantane Glucuronide; 3,5-Dimethyl-1-adamantanamine Glucuronide; NMDA Receptor Antagonist Glucuronide Metabolite; Memantine Major Metabolite; AKOS B018455; BDBM50389357
EINECS	Contact for details

Quality Control

Our Memantine n-B-D-Glucuronide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide a comprehensive Certificate of Analysis (COA) with each shipment, detailing all test results and confirming compliance with specified standards. Our quality commitment ensures material suitable for demanding research and regulatory applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. The product is hygroscopic (moisture-sensitive) and must be handled under dry, inert conditions to maintain stability. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥95.0% (Area Percent)
Water Content (KF)	≤5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.