Description

Bromoacetamido-Peg3-T-Butyl Ester is a specialized bifunctional PEG linker featuring a reactive bromoacetamido group and a protected carboxylic acid. This compound is engineered to facilitate the controlled conjugation of biomolecules, offering a defined spacer arm for precise molecular assembly. It is a critical intermediate for researchers and manufacturers in pharmaceutical development, bioconjugation, and proteomics, where reliable, high-purity building blocks are essential for creating antibody-drug conjugates (ADCs), peptide therapeutics, and diagnostic probes.

Application

• Bioconjugation Reagent: A key building block for site-specific modification of proteins, peptides, and antibodies via thiol or amine coupling.
• Antibody-Drug Conjugate (ADC) Synthesis: Used to create stable, cleavable, or non-cleavable linkers connecting cytotoxic payloads to monoclonal antibodies.
• PEGylation Chemistry: Serves as a heterobifunctional PEG spacer to improve the solubility, stability, and pharmacokinetic profiles of therapeutic molecules.
• Proteomics Research: Employed in the design of activity-based probes (ABPs) and cross-linking agents for studying protein function and interactions.
• Material Science: Functionalizes surfaces and nanoparticles for biosensor development and targeted drug delivery systems.
• Solid-Phase Peptide Synthesis (SPPS): Acts as a versatile handle for introducing PEG chains and reactive groups during peptide chain assembly.

Basic Information

Product Name	Bromoacetamido-Peg3-T-Butyl Ester
CAS No.	1807537-33-2
Molecular Formula	C15H28BrN2O6
Molecular Weight	421.30 g/mol
Synonyms	2-Bromo-N-[2-[2-[2-(2-tert-butoxy-2-oxoethoxy)ethoxy]ethoxy]ethyl]acetamide; Bromoacetamido-PEG3-t-butyl ester; tert-Butyl 2,5,8,11-tetraoxatetradecan-14-oate, 14-bromo-13-oxo-; Bromo-PEG3-acid t-butyl ester; 1-Bromo-2,5,8,11-tetraoxatetradecan-14-oic acid 14-tert-butyl ester; BAPA-PEG3-tBu ester; Bromoacetyl-PEG3-COOtBu
EINECS	Contact for details

Quality Control

Our Bromoacetamido-Peg3-T-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural integrity. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our quality commitment supports applications requiring GMP-grade intermediates for preclinical and clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or oil
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.