Description

Aminoxy-PEG3-Propargyl is a heterobifunctional polyethylene glycol (PEG) linker featuring an aminoxy group and a propargyl group. This compound is essential for creating stable, site-specific bioconjugates through oxime ligation and copper-catalyzed azide-alkyne cycloaddition (CuAAC) click chemistry. It is a critical reagent for researchers and manufacturers in biopharmaceutical development, diagnostic assay production, and advanced materials science, enabling the precise modification of proteins, peptides, and surfaces.

Application

• Bioconjugation and Protein Modification: Site-specific attachment of labels, drugs, or polymers to antibodies, enzymes, and other biomolecules via oxime bond formation.
• ADC (Antibody-Drug Conjugate) Development: Facilitating the construction of stable, homogeneous linker-payload constructs for targeted cancer therapies.
• Surface Functionalization: Modifying nanoparticles, biosensors, and microarray slides with bioorthogonal handles for subsequent click chemistry coupling.
• Polymer Chemistry: Serving as a versatile building block for synthesizing functionalized PEG-based hydrogels, dendrimers, and block copolymers.
• Diagnostic Reagent Synthesis: Creating labeled probes and detection reagents for immunoassays, fluorescence imaging, and molecular diagnostics.
• Chemical Biology Tool Development: Enabling the study of biomolecular interactions and cellular processes through selective tagging and crosslinking.

Basic Information

Product Name	Aminoxy-PEG3-Propargyl
CAS No.	1807537-27-4
Molecular Formula	C12H21NO5
Molecular Weight	259.30 g/mol
Synonyms	Propargyl-PEG3-aminoxy; 3-(2-(2-(3-(Prop-2-yn-1-yloxy)propoxy)ethoxy)ethoxy)propane-1-amine oxime; Aminooxy-PEG3-alkyne; O-(2-Aminooxyethyl)-O'-(2-propynyl)triethylene glycol; Aminoxy-PEG3-Alkyne; 1-Aminooxy-3-[2-[2-(2-prop-2-ynoxyethoxy)ethoxy]ethoxy]propane; PEG3 Aminoxy Propargyl Ether
EINECS	Contact for details

Quality Control

Our Aminoxy-PEG3-Propargyl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided to guarantee the material meets the stringent requirements for research and biopharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) in a dry, cool place. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.