Description

Propargyl-Peg4-Methylamine is a high-purity, heterobifunctional polyethylene glycol (PEG) linker featuring a propargyl group and a primary amine, separated by a tetraethylene glycol spacer. This molecular architecture is critical for creating stable, site-specific conjugations in biopharmaceutical development and advanced material science. It is an essential building block for researchers and manufacturers in the pharmaceutical, diagnostics, and bioconjugation sectors who require reliable, well-characterized linkers for click chemistry and amine-reactive coupling strategies. The compound is supplied under strict quality control to ensure batch-to-batch consistency for sensitive applications.

Application

• Bioconjugation and ADC Development: Site-specific conjugation of payloads (e.g., toxins, dyes, drugs) to antibodies, proteins, or peptides via copper-catalyzed azide-alkyne cycloaddition (CuAAC) click chemistry.
• PEGylation Reagent: Introduction of a hydrophilic PEG spacer to enhance the solubility, stability, and pharmacokinetic properties of therapeutic biomolecules.
• Polymer and Material Science: Functional monomer or crosslinker for synthesizing smart hydrogels, functionalized surfaces, and novel polymeric materials with tailored properties.
• Diagnostic Probe Synthesis: Construction of imaging agents and diagnostic probes by linking targeting moieties to reporter molecules (e.g., fluorophores, radionuclides).
• Solid-Phase Peptide Synthesis (SPPS): Used as a building block to incorporate PEG and click-chemistry handles directly into peptide sequences.
• Nanoparticle Functionalization: Surface modification of liposomes, dendrimers, or inorganic nanoparticles to attach targeting ligands or therapeutic cargo.

Basic Information

Product Name	Propargyl-Peg4-Methylamine
CAS No.	1807530-11-5
Molecular Formula	C15H29NO5
Molecular Weight	303.40 g/mol
Synonyms	Propargyl-PEG4-amine; 2,5,8,11-Tetraoxatetradec-13-yn-14-amine, 14-Azido-3,6,9,12-tetraoxatetradec-1-yne; Propargyl-PEG4-CH2NH2; N-(2-(2-(2-(2-(Prop-2-yn-1-yloxy)ethoxy)ethoxy)ethoxy)ethyl)amine; 1-Amino-3,6,9,12-tetraoxapentadec-14-yne; Propargyl-O-(CH2CH2O)4-CH2CH2NH2; Propargyl PEG4 methylamine; Propargyl tetraethylene glycol methylamine
EINECS	Contact for details

Quality Control

Our Propargyl-Peg4-Methylamine is manufactured under a quality management system and undergoes rigorous analytical testing to ensure it meets the high standards required for research and biopharmaceutical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with relevant guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive). For long-term storage, consider storing under an inert atmosphere (e.g., argon or nitrogen) in a desiccator to maintain stability and purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.