Description

Endo-Bcn-Peg2-Alcohol is a specialized bifunctional polyethylene glycol (PEG) linker featuring an endo-BCN (bicyclo[6.1.0]nonyne) group and a terminal alcohol. This compound is engineered for high-efficiency, copper-free click chemistry applications, enabling rapid and bioorthogonal conjugation under mild physiological conditions. It is an essential reagent for researchers and manufacturers in bioconjugation, pharmaceutical development, and advanced materials science, where precise and stable linkage of biomolecules is required.

Application

• Bioconjugation and Antibody-Drug Conjugate (ADC) Development: Used as a linker to attach cytotoxic payloads, fluorescent dyes, or other functional molecules to antibodies, proteins, or peptides.
• Proteomics and Biomarker Discovery: Facilitates the labeling and enrichment of azide-tagged biomolecules for mass spectrometry analysis and cellular imaging.
• Polymer and Hydrogel Synthesis: Serves as a cross-linking agent or functional monomer to create smart biomaterials with tailored properties for drug delivery and tissue engineering.
• Diagnostic Reagent Formulation: Employed in the development of diagnostic assays and imaging probes that require stable, site-specific labeling.
• Surface Functionalization: Used to modify nanoparticles, chips, or other solid supports with bioorthogonal handles for subsequent capture or detection applications.
• Chemical Biology Tool Development: A key reagent for creating chemical probes to study biological processes in live cells without interfering with native biochemistry.

Basic Information

Product Name	Endo-Bcn-Peg2-Alcohol
CAS No.	1807501-85-4
Molecular Formula	C₁₆H₂₆N₂O₄
Molecular Weight	310.39 g/mol
Synonyms	endo-BCN-PEG2-OH; endo-BCN-PEG2-alcohol; (1R,8S,9s)-Bicyclo[6.1.0]non-4-yn-9-ylmethyl 2,2-dimethyl-14-oxo-3,6,9,12-tetraoxapentadecan-15-oate; 3,6,9,12-Tetraoxapentadecan-15-oic acid, 2,2-dimethyl-14-oxo-, (1R,8S,9s)-bicyclo[6.1.0]non-4-yn-9-ylmethyl ester; BCN-PEG2-OH; DBCO-PEG2-OH (Note: DBCO is often used interchangeably with BCN); Bicyclononyne-PEG2-Alcohol; Azadibenzocyclooctyne-PEG2-Alcohol
EINECS	Contact for details

Quality Control

Our Endo-Bcn-Peg2-Alcohol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment. We support development and production needs across various standards, including cGMP for advanced therapeutic applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile, methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.