Description

Endo-Bcn-Peg4-T-Butyl Ester is a high-purity, bifunctional chemical building block featuring a strained alkyne (BCN) and a protected carboxylic acid group. This compound is specifically engineered for advanced bioconjugation and click chemistry applications, offering excellent reactivity and stability. It is an essential reagent for researchers and manufacturers in pharmaceutical development, proteomics, and materials science who require precise and efficient methods for labeling biomolecules and constructing complex molecular architectures.

Application

• Bioconjugation and Antibody-Drug Conjugate (ADC) Development: Used as a linker-payload component for site-specific conjugation of cytotoxic drugs to antibodies.
• Proteomics and Biomarker Discovery: Enables labeling and enrichment of proteins and peptides for mass spectrometry analysis via strain-promoted azide-alkyne cycloaddition (SPAAC).
• Chemical Biology Tool Development: Serves as a key reagent for synthesizing probes to study enzyme activity, protein interactions, and cellular pathways.
• Polymer and Materials Science: Acts as a functional monomer or cross-linker for creating smart hydrogels, drug delivery systems, and surface-modified materials.
• Diagnostic Reagent Synthesis: Utilized in the production of fluorescent or radioactive tracers for in vitro and in vivo imaging applications.
• Precision Medicine Research: Facilitates the development of targeted therapies by allowing the attachment of various functional moieties to targeting vectors.

Basic Information

Product Name	Endo-Bcn-Peg4-T-Butyl Ester
CAS No.	1807501-83-2
Molecular Formula	C28H49NO9
Molecular Weight	543.70 g/mol
Synonyms	(1R,8S,9s)-Bicyclo[6.1.0]non-4-yn-9-ylmethyl (2,5,8,11-tetraoxatetradecan-14-oate); endo-BCN-PEG4-t-butyl ester; endo-BCN-PEG4-OtBu; (1R,8S,9s)-Bicyclo[6.1.0]non-4-yn-9-ylmethyl 3,6,9,12-tetraoxapentadecanoate; BCN-PEG4-COOtBu; endo-BCN-PEG4-acid t-butyl ester; Tert-butyl 3,6,9,12-tetraoxa-15-((1R,8S,9s)-bicyclo[6.1.0]non-4-yn-9-yl)pentadecanoate
EINECS	Contact for details

Quality Control

Our Endo-Bcn-Peg4-T-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural integrity. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are provided to guarantee batch-to-batch consistency and support your research and cGMP development workflows.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or oil
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solvent Residue (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.