Description

2,4'-Dibromo-3',5'-Difluoroacetophenone is a high-value, multi-halogenated acetophenone derivative, serving as a critical building block in advanced organic synthesis. Its precise molecular architecture makes it an indispensable intermediate for the development of complex pharmaceutical compounds and specialty agrochemicals. This product is essential for research and development chemists and process engineers in the fine chemical, pharmaceutical, and agrochemical industries who require reliable, high-purity intermediates for constructing novel active molecules.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of complex drug candidates, particularly those containing halogenated aromatic systems for enhanced bioactivity and metabolic stability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the dibromo-difluoro substitution pattern contributes to product efficacy and selectivity.
• Material Science Research: Serves as a precursor for the development of novel organic electronic materials, liquid crystals, and specialty polymers.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes and tags for studying biological systems and mechanisms.
• Cross-Coupling Reactions: Acts as a versatile substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) to create complex biaryl structures.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects and contract research organizations (CROs/CMOs) developing proprietary compounds.

Basic Information

Product Name	2,4'-Dibromo-3',5'-Difluoroacetophenone
CAS No.	1807245-37-9
Molecular Formula	C8H4Br2F2O
Molecular Weight	313.92 g/mol
Synonyms	1-(2,4-Dibromo-3,5-difluorophenyl)ethan-1-one; 2',4-Dibromo-3',5'-Difluoroacetophenone; 3',5'-Difluoro-2,4'-dibromoacetophenone; α,2,4-Tribromo-3,5-difluoroacetophenone (incorrect but common misnomer); DBDFAP; Acetophenone, 2,4'-dibromo-3',5'-difluoro-
EINECS	Contact for details

Quality Control

Every batch of 2,4'-Dibromo-3',5'-Difluoroacetophenone is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for sensitive synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for each lot and provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container must be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.