Description

4-Chloro-2,3-Difluorophenylacetonitrile is a versatile and high-purity fluorinated aromatic nitrile building block. This compound is critical for the synthesis of complex molecules, particularly in the pharmaceutical and agrochemical sectors, where its unique halogen and fluorine substitution pattern enables precise modulation of biological activity and physicochemical properties. It serves as a key intermediate for researchers and manufacturers developing active ingredients, advanced materials, and fine chemicals.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of active pharmaceutical ingredients (APIs), especially in the development of kinase inhibitors, anti-cancer agents, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms enhance metabolic stability and bioavailability.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing fluorinated liquid crystals and organic light-emitting diode (OLED) materials, contributing to improved display performance.
• Functional Material Development: Employed in research for creating novel polymers, ligands for catalysis, and other specialty chemicals requiring a difluorophenyl backbone.
• Cross-Coupling Reactions: The nitrile and halogen functionalities make it a valuable substrate for Suzuki, Sonogashira, and other palladium-catalyzed cross-coupling reactions to construct complex biaryl systems.

Basic Information

Item	Detail
Product Name	4-Chloro-2,3-Difluorophenylacetonitrile
CAS No.	1807214-44-3
Molecular Formula	C8H4ClF2N
Molecular Weight	187.57 g/mol
Synonyms	2-(4-Chloro-2,3-difluorophenyl)acetonitrile; (4-Chloro-2,3-difluorophenyl)acetonitrile; 4-Chloro-2,3-difluorobenzeneacetonitrile; α-Cyano-4-chloro-2,3-difluorotoluene; 4-Chloro-2,3-difluoro-α-tolunitrile; 1807214-44-3; 4-Chloro-2,3-difluorophenyl cyanomethyl
EINECS	Contact for details

Quality Control

Every batch of 4-Chloro-2,3-Difluorophenylacetonitrile is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure high purity and consistent batch-to-batch quality. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in opaque packaging or amber glass.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.