Description

1,5-Dibromo-2-Fluoro-3-Iodobenzene is a high-purity, multi-halogenated aromatic building block of significant interest in advanced organic synthesis. Its unique substitution pattern makes it a critical intermediate for constructing complex molecular architectures, particularly in the pharmaceutical and agrochemical sectors. This compound is essential for researchers and process chemists developing active pharmaceutical ingredients (APIs), liquid crystal materials, and specialty ligands for catalysis.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially in medicinal chemistry programs targeting kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, where the fluorine and halogen atoms contribute to biological activity and metabolic stability.
• Material Science Precursor: Serves as a monomer or functionalization agent in the production of specialty polymers, organic semiconductors, and liquid crystal displays (LCDs).
• Cross-Coupling Reactions: An excellent substrate for various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Sonogashira) due to the orthogonal reactivity of its bromo and iodo substituents.
• Chemical Research & Development: A versatile reagent for exploring new synthetic methodologies and creating complex, functionalized benzene derivatives in academic and industrial R&D labs.
• Ligand Synthesis: Used to prepare sophisticated polydentate ligands for coordination chemistry and catalysis.

Basic Information

Product Name	1,5-Dibromo-2-Fluoro-3-Iodobenzene
CAS No.	1807182-16-6
Molecular Formula	C6H2Br2FI
Molecular Weight	403.79 g/mol
Synonyms	2-Fluoro-1,5-dibromo-3-iodobenzene; 3-Iodo-2,6-dibromofluorobenzene; 1,5-Dibromo-2-fluoro-3-iodo-benzene; Benzene, 1,5-dibromo-2-fluoro-3-iodo-; 1807182-16-6; 2,6-Dibromo-3-iodofluorobenzene
EINECS	Contact for details

Quality Control

Our 1,5-Dibromo-2-Fluoro-3-Iodobenzene is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and elemental analysis, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with customer specifications and industry best practices.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.