Description

2-Bromo-3-Fluoroisonicotinonitrile is a high-value, multi-functional heterocyclic building block. This compound is specifically engineered to introduce both bromo and fluoro substituents onto the pyridine ring, enabling precise structural modifications in advanced chemical synthesis. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used in developing new herbicides, fungicides, and insecticides where the fluorine atom enhances biological activity and metabolic stability.
• Material Science: Serves as a building block for creating functionalized ligands, organic semiconductors, and liquid crystal materials.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions for carbon-carbon and carbon-nitrogen bond formation.
• Fluorine Chemistry: Provides a handle for further fluorination or as a stable fluorine-containing moiety in drug discovery to improve lipophilicity and membrane permeability.
• Chemical Biology: Utilized in the design and synthesis of molecular probes and enzyme inhibitors for biochemical research.

Basic Information

Product Name	2-Bromo-3-Fluoroisonicotinonitrile
CAS No.	1805188-90-2
Molecular Formula	C6H2BrFN2
Molecular Weight	200.99 g/mol
Synonyms	3-Fluoro-2-bromoisonicotinonitrile; 2-Bromo-3-fluoropyridine-4-carbonitrile; 4-Cyano-2-bromo-3-fluoropyridine; 3-Fluoro-2-bromo-4-pyridinecarbonitrile; 2-Bromo-3-fluoro-4-cyanopyridine; Isonicotinonitrile, 2-bromo-3-fluoro-; Pyridine-4-carbonitrile, 2-bromo-3-fluoro-
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-3-Fluoroisonicotinonitrile is manufactured and tested under a strict quality management system. We guarantee high chemical purity and lot-to-lot consistency to meet the exacting standards of research and process chemistry. Comprehensive analytical testing, including HPLC, GC, NMR, and MS, is performed. A detailed Certificate of Analysis (COA) with full characterization data is provided with each shipment to ensure complete traceability and compliance with your internal quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong bases and fluorides.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.