Description

1-Chloro-2,3-Dimethoxy-4-Fluorobenzene is a high-purity fluorinated aromatic building block of significant interest in advanced organic synthesis. This compound matters as a versatile intermediate for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific halogen and alkoxy substitution patterns into their target structures.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, especially those targeting the central nervous system or possessing antimicrobial properties.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the fluorine atom enhances biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated aromatic cores in electronic materials, contributing to improved performance in display and lighting technologies.
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution to create complex, multi-substituted benzene derivatives.
• Chemical Research & Development: A valuable reagent for academic and industrial research exploring new synthetic methodologies and material properties.

Basic Information

Product Name	1-Chloro-2,3-Dimethoxy-4-Fluorobenzene
CAS No.	1804409-83-3
Molecular Formula	C8H8ClFO2
Molecular Weight	190.60 g/mol
Synonyms	4-Fluoro-2,3-dimethoxychlorobenzene; 2,3-Dimethoxy-4-fluorochlorobenzene; 1-Chloro-4-fluoro-2,3-dimethoxybenzene; Benzene, 1-chloro-2,3-dimethoxy-4-fluoro-; 4-Fluoro-1-chloro-2,3-dimethoxybenzene; 2,3-Dimethoxy-1-chloro-4-fluorobenzene
EINECS	Contact for details

Quality Control

Our 1-Chloro-2,3-Dimethoxy-4-Fluorobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, impurity profiles, and physical characteristics are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.