Description

5-Bromo-2,4-Difluorobenzodifluoride is a high-purity fluorinated aromatic building block of significant interest in advanced organic synthesis. This compound is valued for its unique reactivity profile, enabling the precise introduction of bromine and fluorine substituents into complex molecular architectures. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in fluorine-containing drug candidates targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the difluorobenzodifluoride moiety enhances biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated aromatic cores for electronic materials, contributing to improved performance in display and lighting technologies.
• Polymer Modification: Employed to introduce fluorine and bromine functional groups into polymer backbones, altering properties like chemical resistance, thermal stability, and surface energy.
• Cross-Coupling Reactions: The bromine atom acts as an excellent handle for palladium-catalyzed reactions (e.g., Suzuki, Stille, Negishi), enabling rapid diversification of the molecular structure.
• Chemical Research & Development: A versatile building block in academic and industrial R&D for exploring new reaction pathways and creating novel fluorinated compounds.

Basic Information

Item	Detail
Product Name	5-Bromo-2,4-Difluorobenzodifluoride
CAS No.	1804408-88-5
Molecular Formula	C7H2BrF4
Molecular Weight	240.99 g/mol
Synonyms	1-Bromo-2,4-difluoro-5-(trifluoromethyl)benzene; 2,4-Difluoro-5-bromobenzotrifluoride; 5-Bromo-2,4-difluoro-α,α,α-trifluorotoluene; 5-Bromo-α,α,α,2,4-pentafluorotoluene; 2,4-Difluoro-5-bromo-α,α,α-trifluorotoluene; Benzene, 1-bromo-2,4-difluoro-5-(trifluoromethyl)-; (5-Bromo-2,4-difluorophenyl)trifluoromethane
EINECS	Contact for details

Quality Control

Our 5-Bromo-2,4-Difluorobenzodifluoride is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and elemental analysis, to ensure high chemical purity and identity confirmation. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical quality attributes. We are committed to consistent batch-to-batch reproducibility to support your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (by GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.