Description

1,5-Dibromo-2-difluoromethoxy-3-fluorobenzene is a high-purity, multi-halogenated aromatic building block of significant interest in advanced organic synthesis. Its unique structure, featuring bromine, fluorine, and a difluoromethoxy group, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and crop protection research.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of fluorine-containing drug candidates where the difluoromethoxy group can enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, leveraging the halogenated benzene core for biological activity.
• Material Science Precursor: Serves as a monomer or functionalization agent in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The bromine substituents are excellent handles for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) to create complex biaryl and conjugated systems.
• Fluorine Chemistry Research: An important substrate for studying the effects of multiple fluorine atoms on molecular conformation, lipophilicity, and reactivity in medicinal and synthetic chemistry.
• Ligand and Catalyst Development: Utilized to synthesize novel chelating ligands or organocatalysts that incorporate halogen and ether functionalities.

Basic Information

Product Name	1,5-Dibromo-2-difluoromethoxy-3-fluorobenzene
CAS No.	1803814-87-0
Molecular Formula	C7H3Br2F3O
Molecular Weight	335.90 g/mol
Synonyms	1,5-Dibromo-2-(difluoromethoxy)-3-fluorobenzene; 2-(Difluoromethoxy)-1,5-dibromo-3-fluorobenzene; 3-Fluoro-1,5-dibromo-2-(difluoromethoxy)benzene; Benzene, 1,5-dibromo-2-(difluoromethoxy)-3-fluoro-; 1,5-Dibromo-3-fluoro-2-(difluoromethoxy)benzene; 2,6-Dibromo-3-fluoroanisole, 2,6-dibromo-3-fluoro-α,α-difluoro-; DFMOB-F-Br2 (common abbreviation)
EINECS	Contact for details

Quality Control

Our 1,5-Dibromo-2-difluoromethoxy-3-fluorobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and elemental analysis, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided to support your R&D and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases and sources of fluoride ions. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.