Description

4-Fluro-3-Methyl-5-Nitroansole is a specialized aromatic nitro compound featuring a fluorine substituent, serving as a high-value intermediate in advanced organic synthesis. This compound matters for its role in constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and functional agrochemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific fluorinated and methoxy-substituted motifs into their target molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders and anti-infective agents.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides, where the fluorine atom enhances biological activity and environmental stability.
• Material Science Research: Employed in the development of organic electronic materials, such as charge-transport layers or fluorinated polymers, due to its electron-withdrawing nitro and fluoro groups.
• Dye and Pigment Intermediate: Acts as a precursor in the manufacture of specialized azo dyes and pigments, contributing to color fastness and unique spectral properties.
• Liquid Crystal & OLED Materials: Serves as a synthetic intermediate for fluorinated components used in liquid crystal displays (LCDs) and organic light-emitting diodes (OLEDs).
• Cross-Coupling Reactions: A valuable substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) for creating biaryl structures common in many functional molecules.

Basic Information

Product Name	4-Fluro-3-Methyl-5-Nitroansole
CAS No.	1803786-01-7
Molecular Formula	C8H8FNO3
Molecular Weight	185.15 g/mol
Synonyms	1-Fluoro-2-methoxy-4-methyl-5-nitrobenzene; 4-Fluoro-3-methyl-5-nitroanisole; 5-Nitro-3-methyl-4-fluoroanisole; Benzene, 1-fluoro-2-methoxy-4-methyl-5-nitro-; 2-Methoxy-4-methyl-5-nitrofluorobenzene
EINECS	Contact for details

Quality Control

Our 4-Fluro-3-Methyl-5-Nitroansole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for research and scale-up applications. Certificates of Analysis (COA) documenting all critical quality attributes are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be amber-colored or stored in light-resistant secondary packaging.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.