Description

2-Amino-3,3-Dimethylbutanenitrile Hydrochloride is a high-purity, protected amino nitrile building block essential for advanced organic synthesis. Its value lies in providing a sterically hindered primary amine group in a stable, crystalline hydrochloride salt form, crucial for constructing complex molecular architectures. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel drug candidates, particularly in the development of protease inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where its unique steric profile can influence biological activity.
• Peptidomimetics Research: Serves as a constrained amino acid analog in the design and synthesis of peptide mimics for biochemical studies and drug discovery.
• Ligand and Catalyst Development: Employed as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis.
• Custom Fine Chemical Production: A versatile starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for clients.
• Academic Research: Utilized in university and institutional laboratories for methodological development in organic chemistry and medicinal chemistry projects.

Basic Information

Product Name	2-Amino-3,3-Dimethylbutanenitrile Hydrochloride
CAS No.	1803596-52-2
Molecular Formula	C6H13N2Cl
Molecular Weight	148.63 g/mol
Synonyms	2-Amino-3,3-dimethylbutyronitrile hydrochloride; 3,3-Dimethyl-2-aminobutanenitrile HCl; tert-Butylglycinonitrile hydrochloride; 2-Amino-2-(tert-butyl)acetonitrile hydrochloride; 2-Cyano-1,1-dimethylethylamine hydrochloride; Amino-tert-butylacetonitrile hydrochloride; (Aminocyanomethyl)trimethylmethane hydrochloride
EINECS	Contact for details

Quality Control

Our 2-Amino-3,3-Dimethylbutanenitrile Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed batch-specific data are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.